| UniProt/SwissProt ID: | STAT4_HUMAN |
| Description: | signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:11365] |
| Location: | chr2 q32.3 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y355 | LPELNyQVKVK | STAT_bind | PhosphoSitePlus |
| S721 | DLLPMsPSVYA | MAPK14 | HPRD |
| Y645 | DILRDyKVIMA | PhosphoSitePlus | |
| Y288 | STKMTyEGDPI | STAT_alpha | PhosphoSitePlus |
| Y693 | RGDKGyVPSVF | JAK_group | phosphoELM; RegPhos |
| T284 | LEEQStKMTYE | STAT_alpha | PhosphoSitePlus |
| S396 | SNGSLsVEFRH | STAT_bind | PhosphoSitePlus |
| T298 | IPMQRtHMLER | STAT_alpha | PhosphoSitePlus |
| S721 | DLLPMsPSVYA | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y693 | RGDKGyVPSVF | JAK1 | RegPhos |
| Y693 | RGDKGyVPSVF | PhosphoSitePlus; HPRD; RegPhos | |
| T287 | QSTKMtYEGDP | STAT_alpha | PhosphoSitePlus |
| S394 | ESSNGsLSVEF | STAT_bind | PhosphoSitePlus |
| S721 | DLLPMsPSVYA | MAP2K6 | HPRD; RegPhos |
| S721 | DLLPMsPSVYA | p38a | RegPhos |
| S386 | NVKAMsIEESS | STAT_bind | PhosphoSitePlus |
| Dephosphorylation site |
| STAT4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376134 | V103A | COSMIC | Prostate Cancer | 20668451 | ENSP00000351255 | E112Q | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000376134 | S547L | COSMIC | Melanoma | 21499247 | ENSP00000376134 | S615C | COSMIC | Breast Cancer | 20668451 | ENSP00000351255 | V103A | COSMIC | Prostate Cancer | 20668451 | ENSP00000376134 | E112Q | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000351255 | H401Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351255 | E520* | COSMIC | Lung Cancer | 20668451 | ENSP00000351255 | S615C | COSMIC | Breast Cancer | 20668451 | ENSP00000376134 | E520* | COSMIC | Lung Cancer | 20668451 | ENSP00000376134 | H401Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351255 | S547L | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000376134 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Up | 4.5 | 15169874 |
| Hyperphosphorylation site |
| STAT4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK1_HUMAN | STAT4_HUMAN | kinase -> substrate | RegPhos |
| MK14_HUMAN | STAT4_HUMAN | kinase -> substrate | HPRD; NetPath |
| ZAGL2_HUMAN | STAT4_HUMAN | kinase -> substrate | RegPhos |
| MP2K6_HUMAN | STAT4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| STAT4_HUMAN | PERF_HUMAN | TF -> target gene | TRANSFAC |
| STAT4_HUMAN | PIM1_HUMAN | TF -> target gene | TRANSFAC |
| STAT4_HUMAN | IRF1_HUMAN | TF -> target gene | TRANSFAC |
| STAT4_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| STAT4_HUMAN | IL2RA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0071310 | cellular response to organic substance | IEA | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |