Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAK2_HUMAN
Description:Janus kinase 2 [Source:HGNC Symbol;Acc:6192]
Location:chr9 p24.1
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S523SDVPTsPTLQRPhosphoSitePlus
Y201TPLAIyNSISYPhosphoSitePlus
Y931KLIMEyLPYGSPkinase_TyrPhosphoSitePlus
Y637GSLDTyLKKNKPkinase_TyrPhosphoSitePlus
Y423NQTGLyVLRCSSH2PhosphoSitePlus
Y1007PQDKEyYKVKEPkinase_TyrPhosphoSitePlus
Y221AKIQDyHILTRPhosphoSitePlus
Y206YNSISyKTFLPJAK2HPRD; RegPhos
Y1007PQDKEyYKVKEABL1HPRD; RegPhos
Y221AKIQDyHILTRJAK2HPRD; RegPhos
Y966CKGMEyLGTKRPkinase_TyrPhosphoSitePlus
Y570REVGDyGQLHEphosphoELM; RegPhos; SysPTM
Y790NNCMDyEPDFRPkinase_TyrPhosphoSitePlus
Y201TPLAIyNSISYJAK2HPRD; RegPhos
Y956IKLLQyTSQICPkinase_TyrPhosphoSitePlus
Y119YRIRFyFPRWYPhosphoSitePlus
Y570REVGDyGQLHEJAK2HPRD; RegPhos; SysPTM
Y1008QDKEYyKVKEPJAK2HPRD; phosphoELM; RegPhos
Y940GSLRDyLQKHKPkinase_TyrPhosphoSitePlus
Y813LFTPDyELLTEJAK2HPRD; RegPhos
Y1007PQDKEyYKVKEJAK2HPRD; phosphoELM; RegPhos
Y570REVGDyGQLHEPkinase_TyrPhosphoSitePlus; SysPTM
S904IEILKsLQHDNPkinase_TyrPhosphoSitePlus
T522VSDVPtSPTLQPhosphoSitePlus
Y435KDFNKyFLTFASH2PhosphoSitePlus
Y813LFTPDyELLTEPhosphoSitePlus; phosphoELM; RegPhos
Y1008QDKEYyKVKEPPkinase_TyrPhosphoSitePlus
Y382ADAHHyLCKEVPhosphoSitePlus
Y1007PQDKEyYKVKEautocatalysisRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1007VLPQDKEyYKVKEPGPTPN11HPRD
Y1008LPQDKEYyKVKEPGEPTPRCHPRD
Y1007VLPQDKEyYKVKEPGPTPRCHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371067K607NHPIacute myeloid leukemia16247455
ENSP00000371067I328VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000371067K191QGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000440387L579PTCGAOvarian Cancer21720365, 18772890
ENSP00000371067V617FHPIacute myeloid leukemia15781101 16325696 15793561 15858187 16707754 16247455 16603627 22315494 22304488 22300941 22289493 22248193 22313642 22227528 22271575 22262773 22262778 22251709 22234689 22234683 21320566 21303356 21287350 21416861 21403427 21283107 22203033
ENSP00000371067V617FOMIMLeukemia15781101 16247455 19036091
ENSP00000371067V1110LBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000371067Y931CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000371067L609SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000371067R1122PDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000371067P503LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000371067K607NOMIMLeukemia16247455
ENSP00000371067L579PTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
JAK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
JAK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK2_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSTAM1_HUMANkinase -> substrateNetPath
JAK2_HUMANJAK2_HUMANkinase -> substrateRegPhos; NetPath
JAK2_HUMANKHDR2_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSYUA_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANEPOR_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
JAK2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANIL6RB_HUMANkinase -> substrateNetPath
JAK2_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANJAK2_HUMANkinase -> substrateHPRD; RegPhos
JAK2_HUMANSTAP2_HUMANkinase -> substrateHPRD
JAK2_HUMANSH2B1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
JAK2_HUMANRAF1_HUMANkinase -> substrateRegPhos
JAK2_HUMANSTA5A_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
JAK2_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
JAK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANEGFR_HUMANkinase -> substrateHPRD; RegPhos
JAK2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANJAK2_HUMANkinase -> substrateRegPhos
JAK2_HUMANPTN11_HUMANkinase -> substrateKEGG
JAK2_HUMANCCR2_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
JAK2_HUMANOBRG_HUMANkinase -> substrateRegPhos
JAK2_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANMED28_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANRSMB_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANM4K5_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSHPS1_HUMANkinase -> substrateHPRD; RegPhos
JAK2_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
JAK2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANGHR_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
JAK2_HUMANSTAT3_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
STK24_HUMANJAK2_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANGTF2I_HUMANkinase -> substrateHPRD; RegPhos
JAK2_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
PTN11_HUMANJAK2_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANJAK2_HUMANphosphatase -> substrateHPRD
SOCS3_HUMANJAK2_HUMANotherKEGG
OBRG_HUMANJAK2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04725Cholinergic synapse
hsa04920Adipocytokine signaling pathway
hsa05168Herpes simplex infection
hsa05145Toxoplasmosis
hsa04062Chemokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05152Tuberculosis
hsa05164Influenza A
hsa05162Measles
hsa05140Leishmaniasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035722interleukin-12-mediated signaling pathwayIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationISSbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0032760positive regulation of tumor necrosis factor produISSbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0030041actin filament polymerizationNASbiological_process
GO:0022408negative regulation of cell-cell adhesionIEAbiological_process
GO:0005131growth hormone receptor bindingIEAmolecular_function
GO:0042508tyrosine phosphorylation of Stat1 proteinIEAbiological_process
GO:0034612response to tumor necrosis factorIDAbiological_process
GO:0008631intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0030218erythrocyte differentiationISSbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayISSbiological_process
GO:0019901protein kinase bindingIDAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0031959mineralocorticoid receptor signaling pathwayIEAbiological_process
GO:0042393histone bindingIEAmolecular_function
GO:0033194response to hydroperoxideIEAbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0007259JAK-STAT cascadeIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0097296activation of cysteine-type endopeptidase activityISSbiological_process
GO:0033160positive regulation of protein import into nucleusIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayISSbiological_process
GO:0007165signal transductionISSbiological_process
GO:0050867positive regulation of cell activationIEAbiological_process
GO:0031103axon regenerationIEAbiological_process
GO:0042506tyrosine phosphorylation of Stat5 proteinIEAbiological_process
GO:0030154cell differentiationISSbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0043388positive regulation of DNA bindingIEAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayIEAbiological_process
GO:0032516positive regulation of phosphoprotein phosphatase IEAbiological_process
GO:0007498mesoderm developmentTASbiological_process
GO:0005143interleukin-12 receptor bindingIEAmolecular_function
GO:0043392negative regulation of DNA bindingIEAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0004672protein kinase activityNASmolecular_function
GO:0035401histone kinase activity (H3-Y41 specific)IDAmolecular_function
GO:0045822negative regulation of heart contractionIEAbiological_process
GO:0042503tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0032731positive regulation of interleukin-1 beta productiIEAbiological_process
GO:0061180mammary gland epithelium developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0051428peptide hormone receptor bindingIEAmolecular_function
GO:0016363nuclear matrixIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005901caveolaIEAcellular_component
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0035409histone H3-Y41 phosphorylationIDAbiological_process
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalISSbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0031702type 1 angiotensin receptor bindingIEAmolecular_function
GO:0006915apoptotic processISSbiological_process
GO:0004713protein tyrosine kinase activityISSmolecular_function
GO:0007262STAT protein import into nucleusIEAbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0070671response to interleukin-12IDAbiological_process
GO:0046677response to antibioticIDAbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0046777protein autophosphorylationISSbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0007260tyrosine phosphorylation of STAT proteinISSbiological_process
GO:0033209tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0006919activation of cysteine-type endopeptidase activityISSbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0010811positive regulation of cell-substrate adhesionIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0031904endosome lumenTAScellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryISSbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0050727regulation of inflammatory responseIDAbiological_process
GO:0033130acetylcholine receptor bindingIEAmolecular_function
GO:0051770positive regulation of nitric-oxide synthase biosyIEAbiological_process
GO:0007260tyrosine phosphorylation of STAT proteinIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045121membrane raftISScellular_component
GO:0005829cytosolIEAcellular_component
GO:0042977activation of JAK2 kinase activityISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0020037heme bindingIDAmolecular_function
GO:0060399positive regulation of growth hormone receptor sigISSbiological_process
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0006928cellular component movementTASbiological_process