Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCOA2_HUMAN
Description:nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:7669]
Location:chr8 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S698LLQDSsSPVDLHPRD
S719DLSQEsSSTAPPhosphoSitePlus
T456SGMQAtTPQGSHPRD
S499PGVAGsPRIPPPhosphoSitePlus; HPRD
S736KQEPVsPKKKEPhosphoSitePlus; HPRD; phosphoELM
S726STAPGsEVTIKPhosphoSitePlus; HPRD
S487PTSMLsPRHRMPhosphoSitePlus; HPRD
S655DQMEPsPLASSSRC-1PhosphoSitePlus
T729PGSEVtIKQEPHPRD
S493PRHRMsPGVAGPhosphoSitePlus; HPRD; SysPTM
S660SPLASsLSDTNSRC-1PhosphoSitePlus
S721SQESSsTAPGSHPRD
S851LTAENsPVTPVPhosphoSitePlus; HPRD
S469ALKMNsPSQSSPhosphoSitePlus; HPRD
S699LQDSSsPVDLAHPRD; phosphoELM; SysPTM
S698LLQDSsSPVDLSRC-1PhosphoSitePlus
S699LQDSSsPVDLASRC-1PhosphoSitePlus; SysPTM
S161NKSVYsILHVGPASPhosphoSitePlus
T681GSTHGtSLKEKHPRD
S671KDSTGsLPGSGSRC-1PhosphoSitePlus
S668DTNKDsTGSLPHPRD
T773RLDSKtDPASNPhosphoSitePlus
S29DQLGPsPKRNTPhosphoSitePlus; HPRD
Y747NALLRyLLDKDPhosphoSitePlus
T854ENSPVtPVGAQPhosphoSitePlus; HPRD
S2____MsGMGENPhosphoSitePlus
S565GNLQNsPVNMNPhosphoSitePlus; HPRD
S474SPSQSsPGMNPPhosphoSitePlus; HPRD
T457GMQATtPQGSNPhosphoSitePlus
T669TNKDStGSLPGSRC-1PhosphoSitePlus
S471KMNSPsQSSPGHPRD
S771LERLDsKTDPAPhosphoSitePlus
S716TGKDLsQESSSPhosphoSitePlus; HPRD
T722QESSStAPGSEHPRD

Dephosphorylation site
NCOA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399968G725VCOSMICLung Cancer20668451
ENSP00000399968M391RBIOMARTBreast Cancer21930507, 21930502
ENSP00000399968P470SCOSMICMelanoma
ENSP00000399968L1206RCOSMICOvarian Cancer21720365
ENSP00000399968Q1032ECOSMICLung Cancer
ENSP00000399968G518VCOSMICLung Cancer20668451
ENSP00000399968E849KCOSMICBreast Cancer20668451
ENSP00000399968G598VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000399968G439DCOSMICMelanoma
ENSP00000399968I162MCOSMICBreast Cancer20668451
ENSP00000399968Q1116HCOSMICLung Cancer20668451

Differential expressed protein
NCOA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCOA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGR_HUMANNCOA2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NCOA2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coIEAmolecular_function
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0004402histone acetyltransferase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0030375thyroid hormone receptor coactivator activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0016922ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005634nucleusNAScellular_component
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030521androgen receptor signaling pathwayRCAbiological_process
GO:0035257nuclear hormone receptor bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003713transcription coactivator activityNASmolecular_function


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