| UniProt/SwissProt ID: | NCOA2_HUMAN |
| Description: | nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:7669] |
| Location: | chr8 q13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S698 | LLQDSsSPVDL | HPRD | |
| S719 | DLSQEsSSTAP | PhosphoSitePlus | |
| T456 | SGMQAtTPQGS | HPRD | |
| S499 | PGVAGsPRIPP | PhosphoSitePlus; HPRD | |
| S736 | KQEPVsPKKKE | PhosphoSitePlus; HPRD; phosphoELM | |
| S726 | STAPGsEVTIK | PhosphoSitePlus; HPRD | |
| S487 | PTSMLsPRHRM | PhosphoSitePlus; HPRD | |
| S655 | DQMEPsPLASS | SRC-1 | PhosphoSitePlus |
| T729 | PGSEVtIKQEP | HPRD | |
| S493 | PRHRMsPGVAG | PhosphoSitePlus; HPRD; SysPTM | |
| S660 | SPLASsLSDTN | SRC-1 | PhosphoSitePlus |
| S721 | SQESSsTAPGS | HPRD | |
| S851 | LTAENsPVTPV | PhosphoSitePlus; HPRD | |
| S469 | ALKMNsPSQSS | PhosphoSitePlus; HPRD | |
| S699 | LQDSSsPVDLA | HPRD; phosphoELM; SysPTM | |
| S698 | LLQDSsSPVDL | SRC-1 | PhosphoSitePlus |
| S699 | LQDSSsPVDLA | SRC-1 | PhosphoSitePlus; SysPTM |
| S161 | NKSVYsILHVG | PAS | PhosphoSitePlus |
| T681 | GSTHGtSLKEK | HPRD | |
| S671 | KDSTGsLPGSG | SRC-1 | PhosphoSitePlus |
| S668 | DTNKDsTGSLP | HPRD | |
| T773 | RLDSKtDPASN | PhosphoSitePlus | |
| S29 | DQLGPsPKRNT | PhosphoSitePlus; HPRD | |
| Y747 | NALLRyLLDKD | PhosphoSitePlus | |
| T854 | ENSPVtPVGAQ | PhosphoSitePlus; HPRD | |
| S2 | ____MsGMGEN | PhosphoSitePlus | |
| S565 | GNLQNsPVNMN | PhosphoSitePlus; HPRD | |
| S474 | SPSQSsPGMNP | PhosphoSitePlus; HPRD | |
| T457 | GMQATtPQGSN | PhosphoSitePlus | |
| T669 | TNKDStGSLPG | SRC-1 | PhosphoSitePlus |
| S471 | KMNSPsQSSPG | HPRD | |
| S771 | LERLDsKTDPA | PhosphoSitePlus | |
| S716 | TGKDLsQESSS | PhosphoSitePlus; HPRD | |
| T722 | QESSStAPGSE | HPRD | |
| Dephosphorylation site |
| NCOA2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000399968 | G725V | COSMIC | Lung Cancer | 20668451 | ENSP00000399968 | M391R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000399968 | P470S | COSMIC | Melanoma | ENSP00000399968 | L1206R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000399968 | Q1032E | COSMIC | Lung Cancer | ENSP00000399968 | G518V | COSMIC | Lung Cancer | 20668451 | ENSP00000399968 | E849K | COSMIC | Breast Cancer | 20668451 | ENSP00000399968 | G598V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000399968 | G439D | COSMIC | Melanoma | ENSP00000399968 | I162M | COSMIC | Breast Cancer | 20668451 | ENSP00000399968 | Q1116H | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| NCOA2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NCOA2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FGR_HUMAN | NCOA2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NCOA2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0030374 | ligand-dependent nuclear receptor transcription co | IEA | molecular_function |
| GO:0044255 | cellular lipid metabolic process | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0030374 | ligand-dependent nuclear receptor transcription co | IDA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0004402 | histone acetyltransferase activity | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0030375 | thyroid hormone receptor coactivator activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0016922 | ligand-dependent nuclear receptor binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0003713 | transcription coactivator activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030521 | androgen receptor signaling pathway | RCA | biological_process |
| GO:0035257 | nuclear hormone receptor binding | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | NAS | molecular_function |