| UniProt/SwissProt ID: | PXK_HUMAN |
| Description: | PX domain containing serine/threonine kinase [Source:HGNC Symbol;Acc:23326] |
| Location: | chr3 p14.3 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y163 | RIRKKyFLMKI | PhosphoSitePlus | |
| S57 | IVRRYsDFDLL | PX | PhosphoSitePlus |
| T563 | NFQKGtLRKAK | WH2 | PhosphoSitePlus |
| T444 | QHRRLtRAQSH | PhosphoSitePlus | |
| S467 | LARKKsKRSAL | PhosphoSitePlus | |
| S452 | QSHHGsEEERK | PhosphoSitePlus | |
| S470 | KKSKRsALENS | PhosphoSitePlus | |
| Y56 | QIVRRySDFDL | PX | PhosphoSitePlus |
| S448 | LTRAQsHHGSE | PhosphoSitePlus | |
| Dephosphorylation site |
| PXK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PXK_HUMAN do not have mutation site. |
| Differential expressed protein |
| PXK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PXK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PXK_HUMAN | KPCB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | SOX10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | UB2L3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | FGR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | KPCD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | WIPI3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PXK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0050804 | regulation of synaptic transmission | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0050804 | regulation of synaptic transmission | ISS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006954 | inflammatory response | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0032780 | negative regulation of ATPase activity | IEA | biological_process |
| GO:0008022 | protein C-terminus binding | IEA | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0043271 | negative regulation of ion transport | IEA | biological_process |