Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOC2L_HUMAN
Description:nucleolar complex associated 2 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:24517]
Location:chr1 p36.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T616EGTPLtLYYSHNoc2PhosphoSitePlus
S58PGGSPsASRRKPhosphoSitePlus; HPRD
S710EGEEDsSNSEDPhosphoSitePlus; HPRD
S682DTEGFsERGILHPRD
S691ILRPLsTRHGVHPRD
T15RLAELtVDEFLPhosphoSitePlus
S67RKGRAsEHKDQHPRD
S56DKPGGsPSASRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S620LTLYYsHWRKLNoc2PhosphoSitePlus
S746EDLQLsEHPRD; phosphoELM
S60GSPSAsRRKGRPhosphoSitePlus; HPRD
S28GFDSEsESESEPhosphoSitePlus; HPRD; phosphoELM
S112EGPFHsLPDVLHPRD
S30DSESEsESENSHPRD; phosphoELM
S35SESENsPQAETPhosphoSitePlus; HPRD; phosphoELM
S32ESESEsENSPQHPRD; phosphoELM
T678SEEDDtEGFSEPhosphoSitePlus; HPRD; phosphoELM
Y618TPLTLyYSHWRNoc2PhosphoSitePlus
S102FSDSDsSEEEEHPRD; phosphoELM
S103SDSDSsEEEEGHPRD; phosphoELM
S22DEFLAsGFDSEHPRD
S49REAARsPDKPGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S238RMLQPsSSPLWPhosphoSitePlus
T40SPQAEtREAREPhosphoSitePlus
S711GEEDSsNSEDGPhosphoSitePlus; HPRD
S240LQPSSsPLWGKHPRD
S673FDLNSsEEDDTPhosphoSitePlus; HPRD; phosphoELM
Y533DLTLEyLHSQANoc2PhosphoSitePlus
S93QENDQsLLNFSHPRD; phosphoELM
S713EDSSNsEDGDPPhosphoSitePlus; HPRD
S672LFDLNsSEEDDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S100LNFSDsDSSEEHPRD; phosphoELM
S26ASGFDsESESEPhosphoSitePlus; HPRD; phosphoELM
S746EDLQLsEDD__PhosphoSitePlus
S98SLLNFsDSDSSHPRD; phosphoELM
S121VLEEAsEEEDGPhosphoSitePlus; HPRD

Dephosphorylation site
NOC2L_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317992G108RCOSMICSkin Cancer21984974
ENSP00000317992N565HCOSMICOvarian Cancer21720365
ENSP00000317992S67PCOSMICOvarian Cancer21720365

Differential expressed protein
NOC2L_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NOC2L_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK7_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NOC2L_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070491repressing transcription factor bindingIDAmolecular_function
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005678chromatin assembly complexIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0032066nucleolus to nucleoplasm transportIDAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0042393histone bindingIDAmolecular_function
GO:0035067negative regulation of histone acetylationIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005488bindingIEAmolecular_function
GO:0005654nucleoplasmIDAcellular_component
GO:0031491nucleosome bindingIDAmolecular_function
GO:0002903negative regulation of B cell apoptotic processIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0034644cellular response to UVIDAbiological_process


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