| UniProt/SwissProt ID: | BRSK2_HUMAN |
| Description: | BR serine/threonine kinase 2 [Source:HGNC Symbol;Acc:11405] |
| Location: | chr11 p15.5 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T174 | DSLLEtSCGSP | LKB1 | phosphoELM |
| S412 | GQRSRsISGAS | PhosphoSitePlus | |
| T509 | EMSNLtPESSP | PhosphoSitePlus | |
| S489 | NSFLGsPRFHR | PhosphoSitePlus; HPRD; phosphoELM | |
| S423 | SGLSTsPLSSP | PhosphoSitePlus; HPRD | |
| S393 | VTDGGsPVPAR | PhosphoSitePlus; HPRD | |
| T260 | AARRLtLEHIQ | Pkinase | PhosphoSitePlus |
| S367 | RKRVDsPMLNR | PhosphoSitePlus | |
| S382 | RPERKsMEVLS | PhosphoSitePlus; HPRD | |
| T431 | SSPRVtPHPSP | PhosphoSitePlus | |
| S466 | NPTPPsSPSVG | PhosphoSitePlus | |
| S178 | ETSCGsPHYAC | RegPhos | |
| S294 | IRSLPsLEDID | PhosphoSitePlus | |
| S410 | QHGQRsRSISG | PhosphoSitePlus | |
| S427 | TSPLSsPRVTP | PhosphoSitePlus | |
| S512 | NLTPEsSPELA | PhosphoSitePlus | |
| T463 | GTPNPtPPSSP | PhosphoSitePlus | |
| S439 | PSPRGsPLPTP | PhosphoSitePlus | |
| Y15 | AQHAQyVGPYR | PhosphoSitePlus | |
| S481 | RARLNsIKNSF | PhosphoSitePlus | |
| T174 | DSLLEtSCGSP | RegPhos | |
| T422 | SSGLStSPLSS | RegPhos | |
| S513 | LTPESsPELAK | PhosphoSitePlus | |
| T174 | DSLLEtSCGSP | Pkinase | PhosphoSitePlus |
| S426 | STSPLsSPRVT | PhosphoSitePlus | |
| T174 | DSLLEtSCGSP | LKB1(STK11 | RegPhos |
| S435 | VTPHPsPRGSP | PhosphoSitePlus | |
| Dephosphorylation site |
| BRSK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000310697 | P277S | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| BRSK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BRSK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | BRSK2_HUMAN | kinase -> substrate | RegPhos |
| BRSK2_HUMAN | MPIP3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| BRSK2_HUMAN | WEE1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| STK11_HUMAN | BRSK2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| WEE1_HUMAN | BRSK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BRSK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070059 | intrinsic apoptotic signaling pathway in response | IMP | biological_process |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0007409 | axonogenesis | IEA | biological_process |
| GO:0030182 | neuron differentiation | IEA | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0031532 | actin cytoskeleton reorganization | IMP | biological_process |
| GO:0006887 | exocytosis | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0061178 | regulation of insulin secretion involved in cellul | IEA | biological_process |
| GO:0030182 | neuron differentiation | ISS | biological_process |
| GO:0030010 | establishment of cell polarity | IEA | biological_process |
| GO:0050321 | tau-protein kinase activity | IEA | molecular_function |
| GO:0048812 | neuron projection morphogenesis | IEA | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000086 | G2/M transition of mitotic cell cycle | IMP | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005813 | centrosome | IDA | cellular_component |