Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BRSK1_HUMAN
Description:BR serine/threonine kinase 1 [Source:HGNC Symbol;Acc:18994]
Location:chr19 q13.42
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S399RPERKsMEVLSPhosphoSitePlus
S413AGGGGsPVPTRPhosphoSitePlus
S587LTPESsPELAKPhosphoSitePlus
T205DSLLEtSCGSPLKB1(STK11RegPhos
S427EMAQHsQRSRSPhosphoSitePlus
T583EMSSLtPESSPPhosphoSitePlus
S447SSPLSsPRSPVPhosphoSitePlus
T205DSLLEtSCGSPRegPhos
S275PEKRLsLEQIQPkinasePhosphoSitePlus
T772KKLLAtNGTPLPhosphoSitePlus
T189DSLLEtSCGSPPkinasePhosphoSitePlus
S209ETSCGsPHYACRegPhos
T205DSLLEtSCGSPLKB1phosphoELM

Dephosphorylation site
BRSK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000310649V319IGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000310649P194LCOSMICSkin Cancer21984974
ENSP00000310649D383YCOSMICOvarian Cancer21720365
ENSP00000310649G327DTCGAOvarian Cancer21720365, 18772890
ENSP00000310649Q58HBIOMARTBreast Cancer21930507, 21930502
ENSP00000310649R303WGreenman2007Gastric Cancer17344846, 18428421
ENSP00000310649G391EGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
BRSK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BRSK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BRSK1_HUMANMPIP2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANBRSK1_HUMANkinase -> substrateRegPhos
STK11_HUMANBRSK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BRSK1_HUMANWEE1_HUMANkinase -> substrateHPRD; RegPhos
BRSK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
BRSK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009411response to UVIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0030182neuron differentiationISSbiological_process
GO:0005524ATP bindingICmolecular_function
GO:0005813centrosomeIEAcellular_component
GO:0030010establishment of cell polarityIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0050321tau-protein kinase activityIEAmolecular_function
GO:0030054cell junctionIDAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007269neurotransmitter secretionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0008021synaptic vesicleIEAcellular_component
GO:0030182neuron differentiationIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0031572G2/M transition DNA damage checkpointIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0051298centrosome duplicationIEAbiological_process
GO:0043015gamma-tubulin bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component


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