| UniProt/SwissProt ID: | ZBTB4_HUMAN |
| Description: | zinc finger and BTB domain containing 4 [Source:HGNC Symbol;Acc:23847] |
| Location: | chr17 p13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S687 | ASVGGsGLPRG | PhosphoSitePlus | |
| T266 | STRGStGLGAG | PhosphoSitePlus | |
| S265 | ASTRGsTGLGA | PhosphoSitePlus | |
| S391 | AFHGIsPGLLA | PhosphoSitePlus; HPRD | |
| S105 | SASSSsSSSSS | BTB | PhosphoSitePlus |
| S88 | AASSSsSSSSS | BTB | PhosphoSitePlus |
| S87 | TAASSsSSSSS | BTB | PhosphoSitePlus |
| S104 | SSASSsSSSSS | BTB | PhosphoSitePlus |
| S89 | ASSSSsSSSSS | BTB | PhosphoSitePlus |
| S107 | SSSSSsSSSSP | BTB | PhosphoSitePlus |
| S106 | ASSSSsSSSSS | BTB | PhosphoSitePlus |
| S683 | AAGGAsVGGSG | PhosphoSitePlus | |
| S90 | SSSSSsSSSSS | BTB | PhosphoSitePlus |
| Y415 | NTLKLyRLLPM | PhosphoSitePlus | |
| T797 | PGGTPtPVIAY | PhosphoSitePlus | |
| T795 | ERPGGtPTPVI | PhosphoSitePlus; HPRD | |
| T983 | PPAPPtPPPPT | PhosphoSitePlus | |
| Dephosphorylation site |
| ZBTB4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000369973 | A862V | COSMIC | Melanoma | 21499247 | ENSP00000369973 | L879F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000369973 | L948F | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000307858 | S284L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000369973 | R906Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000369973 | S284L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000307858 | L879F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000307858 | R906Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ZBTB4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZBTB4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| WEE1_HUMAN | ZBTB4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | ZBTB4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZBTB4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |