| UniProt/SwissProt ID: | MAGD1_HUMAN |
| Description: | melanoma antigen family D, 1 [Source:HGNC Symbol;Acc:6813] |
| Location: | chrX p11.22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S643 | SYHETsKMKVL | MAGE | PhosphoSitePlus |
| S457 | PNSRAsQNPGA | PhosphoSitePlus | |
| T160 | VGPNAtYNFSQ | PhosphoSitePlus | |
| S129 | AAYDFsQAATT | PhosphoSitePlus | |
| Y630 | SNPPEyEFLWG | MAGE | PhosphoSitePlus |
| Y126 | GPNAAyDFSQA | PhosphoSitePlus | |
| Y92 | GPNGVyDFSQA | PhosphoSitePlus; HPRD; phosphoELM | |
| T312 | GWQNQtARQTP | PhosphoSitePlus | |
| T85 | VQNATtKGPNG | PhosphoSitePlus | |
| Y481 | NKLVKyLMLKD | MAGE | PhosphoSitePlus |
| T274 | PLAAGtWRSAP | PhosphoSitePlus | |
| S638 | LWGLRsYHETS | MAGE | PhosphoSitePlus |
| Y148 | GPNGVyDFSQA | HPRD | |
| T642 | RSYHEtSKMKV | MAGE | PhosphoSitePlus |
| S95 | GVYDFsQAHNA | PhosphoSitePlus | |
| Y161 | GPNATyNFSQS | PhosphoSitePlus | |
| Dephosphorylation site |
| MAGD1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364874 | S76A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000364927 | S76A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000364847 | S132A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000364847 | K131* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364847 | W783* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000325333 | S76A | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000325333 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| MAGD1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK2_HUMAN | MAGD1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MAGD1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0050680 | negative regulation of epithelial cell proliferati | IDA | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0003713 | transcription coactivator activity | IEA | molecular_function |
| GO:0090190 | positive regulation of branching involved in urete | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043406 | positive regulation of MAP kinase activity | IEA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0043234 | protein complex | IDA | cellular_component |