Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GDIR2_HUMAN
Description:Rho GDP dissociation inhibitor (GDI) beta [Source:HGNC Symbol;Acc:679]
Location:chr12 p12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T60DGPVVtDPKAPRho_GDIPhosphoSitePlus
T157EYEFLtPVEEARho_GDIPhosphoSitePlus
S20DDELDsKLNYKRho_GDIPhosphoSitePlus
Y48ESLIKyKKTLLRho_GDIPhosphoSitePlus
Y24DSKLNyKPPPQHPRD; phosphoELM
S31PPPQKsLKELQRho_GDIPhosphoSitePlus
Y130YVQHTyRTGVKRho_GDIPhosphoSitePlus
Y146FMVGSyGPRPERho_GDIPhosphoSitePlus
S145TFMVGsYGPRPRho_GDIPhosphoSitePlus
Y153PRPEEyEFLTPRho_GDIPhosphoSitePlus
Y24DSKLNyKPPPQRho_GDIPhosphoSitePlus
T51IKYKKtLLGDGRho_GDIPhosphoSitePlus

Dephosphorylation site
GDIR2_HUMAN do not have dephosphorylation site.

Mutation site
GDIR2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000228945Hepatocellular CarcinomaNormal vs. CancertissueDown0.3415759316
ENSP00000228945Oral CancerNormal vs. CancertissueUp2.616889763
ENSP00000228945Hepatocellular CarcinomaNormal vs. CancertissueDown18937283
ENSP00000228945hepatitis B virusNormal vs. CancertissueUp4.820525558
ENSP00000228945Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217
ENSP00000228945Breast CancerMetastasiscell lineUp20155427
ENSP00000228945Breast CancerNormal vs. Cancercell lineDown0.4520543960
ENSP00000228945Oral CancerNormal vs. CancertissueUp3.119691830
ENSP00000228945LeukemiaNormal vs. CancertissueDown15501966
ENSP00000228945acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000228945acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000228945acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1317655343
ENSP00000228945acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp8.417655343
ENSP00000228945acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000228945Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.819714814

Hyperphosphorylation site
GDIR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANGDIR2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
GDIR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007275multicellular organismal developmentTASbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0005856cytoskeletonTAScellular_component
GO:0005096GTPase activator activityIEAmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0006955immune responseTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005094Rho GDP-dissociation inhibitor activityIEAmolecular_function
GO:0007266Rho protein signal transductionTASbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleTAScellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0007162negative regulation of cell adhesionTASbiological_process
GO:0005829cytosolTAScellular_component


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