Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K5_HUMAN
Description:mitogen-activated protein kinase kinase kinase 5 [Source:HGNC Symbol;Acc:6857]
Location:chr6 q23.3
Node attribute:ubiquitination(target); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S83RGRGSsVGGGSAKT_groupRegPhos
S964NEYLRsISLPVPhosphoSitePlus
S83RGRGSsVGGGSAKT1HPRD; RegPhos
S1033HSAPPsPEEKDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S83RGRGSsVGGGSAkt2(PKB betaRegPhos
S1029NFEDHsAPPSPPhosphoSitePlus; HPRD; phosphoELM
Y574IYQPSyLSINNPhosphoSitePlus
Y814VLINTySGVLKPkinasePhosphoSitePlus
T813NVLINtYSGVLPkinasePhosphoSitePlus
S1240QSAHRsLNVQLPhosphoSitePlus
T842ETFTGtLQYMAHPRD; RegPhos
S966YLRSIsLPVPVMAP3K5phosphoELM; RegPhos
Y718ERDSRySQPLHPkinasePhosphoSitePlus
Y982SSSSEyGSVSPPhosphoSitePlus
T842ETFTGtLQYMAPkinasePhosphoSitePlus
T838NPCTEtFTGTLMAP3K5HPRD; RegPhos
S83RGRGSsVGGGSPhosphoSitePlus
S986EYGSVsPDTELPhosphoSitePlus
T838NPCTEtFTGTLPDK1RegPhos
T838NPCTEtFTGTLPDK-1phosphoELM
S966YLRSIsLPVPVPhosphoSitePlus; HPRD; RegPhos
S958ALSAGsNEYLRPhosphoSitePlus; RegPhos
T838NPCTEtFTGTLphosphoELM; RegPhos
S83RGRGSsVGGGSPKB_groupphosphoELM
S461GVKLSsLLGKKDUF4071PhosphoSitePlus
T838NPCTEtFTGTLPkinasePhosphoSitePlus
S83RGRGSsVGGGSPKB_betaphosphoELM
T528HFVKLtTEQPVDUF4071PhosphoSitePlus
Y570EPTKIyQPSYLPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T842CTETFTGtLQYMAPEPPP5CHPRD

Mutation site
M3K5_HUMAN do not have mutation site.

Differential expressed protein
M3K5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K5_HUMANMP2K4_HUMANkinase -> substrateRegPhos
M3K5_HUMANMP2K6_HUMANkinase -> substrateKEGG
AKT3_HUMANM3K5_HUMANkinase -> substrateKEGG
M3K5_HUMANM3K5_HUMANkinase -> substrateRegPhos
AKT1_HUMANM3K5_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANM3K5_HUMANkinase -> substrateRegPhos
PDPK1_HUMANM3K5_HUMANkinase -> substrateRegPhos
M3K5_HUMANTNNT2_HUMANkinase -> substrateRegPhos
FAK2_HUMANM3K5_HUMANkinase -> substrateRobert H Newman (2013)
M3K5_HUMANMP2K3_HUMANkinase -> substrateKEGG
PPP5_HUMANM3K5_HUMANphosphatase -> substrateHPRD; KEGG
BIRC2_HUMANM3K5_HUMANubiquitinationNetPath
DAXX_HUMANM3K5_HUMANotherKEGG
TRAF2_HUMANM3K5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04722Neurotrophin signaling pathway
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008631intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0097190apoptotic signaling pathwayTASbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0010941regulation of cell deathIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008656cysteine-type endopeptidase activator activity invIDAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0045087innate immune responseIEAbiological_process
GO:0007254JNK cascadeIDAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0000165MAPK cascadeIDAbiological_process
GO:0070301cellular response to hydrogen peroxideIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0010421hydrogen peroxide-mediated programmed cell deathIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0019048virus-host interactionIEAbiological_process


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