Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THIO_HUMAN
Description:thioredoxin [Source:HGNC Symbol;Acc:12435]
Location:chr9 q31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T100EKLEAtINEphosphoELM
T100EKLEAtINELVThioredoxinPhosphoSitePlus

Dephosphorylation site
THIO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363641*106CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363641Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000363641Neoplasms by Histologic TypeNormal vs. CancertissueUp1.918259946
ENSP00000363641Hepatocellular CarcinomaNormal vs. CancertissueUp16335951
ENSP00000363641Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueUp17593366
ENSP00000363641Hepatocellular CarcinomaNormal vs. CancertissueUp1.819956837
ENSP00000363641Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000363641Breast CancerMetastasiscell lineDown0.2218582095
ENSP00000363641Breast CancerNormal vs. CancertissueUp3.320005186
ENSP00000363641Breast CancerNormal vs. Cancercell lineUp1.620543960
ENSP00000363641Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000363641Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000363641acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp9.717655343
ENSP00000363641Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.7420625496

Hyperphosphorylation site
THIO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK1_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
THIO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0033158regulation of protein import into nucleus, transloIDAbiological_process
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0019899enzyme bindingIEAmolecular_function
GO:0046826negative regulation of protein export from nucleusIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0007067mitosisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035690cellular response to drugIEAbiological_process
GO:0009314response to radiationIDAbiological_process
GO:0015949nucleobase-containing small molecule interconversiTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0071455cellular response to hyperoxiaIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0010269response to selenium ionIEAbiological_process
GO:0043388positive regulation of DNA bindingIDAbiological_process
GO:0015037peptide disulfide oxidoreductase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005681spliceosomal complexIEAcellular_component
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0006662glycerol ether metabolic processIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0015035protein disulfide oxidoreductase activityIEAmolecular_function
GO:0022900electron transport chainIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0014823response to activityIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0055114oxidation-reduction processIDAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0009055electron carrier activityIEAmolecular_function
GO:0045454cell redox homeostasisIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0097068response to thyroxine stimulusIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0016999antibiotic metabolic processIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0071548response to dexamethasone stimulusIEAbiological_process


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