Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN12_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 12 [Source:HGNC Symbol;Acc:9645]
Location:chr7 q11.23
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T598TPLSFtNPLHSHPRD; RegPhos
S613SDERNsDGAVTPhosphoSitePlus; HPRD; phosphoELM
S649KVLPMsIARHNPhosphoSitePlus
S39RLRRLsTKYRTPKC_groupphosphoELM; RegPhos
S332PEKQDsPPPKPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S39RLRRLsTKYRTPRKACAHPRD
T593SPLFRtPLSFTHPRD
S39RLRRLsTKYRTPKCaRegPhos
S571VSLTPsPTTQVPhosphoSitePlus; HPRD; phosphoELM
S39RLRRLsTKYRTPhosphoSitePlus
S673DVSEDsPPPLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y42RLSTKyRTEKIHPRD
T569KTVSLtPSPTTPhosphoSitePlus; HPRD; phosphoELM
S608SDDSDsDERNSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S606LHSDDsDSDERPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S39RLRRLsTKYRTPRKCAHPRD
S186EFQNEsRRLYQRegPhos
S588DHDNTsPLFRTPhosphoSitePlus; HPRD; phosphoELM
S567TRKTVsLTPSPPhosphoSitePlus; HPRD; phosphoELM
S449QEGPKsFDGNTPhosphoSitePlus; HPRD
S435LERNLsFEIKKPRKACAHPRD; SysPTM
S603TNPLHsDDSDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S19VQAMKsPDHNGPhosphoSitePlus; HPRD
T519SQNSDtPPRPDPhosphoSitePlus; HPRD; phosphoELM
S435LERNLsFEIKKPKCa(PKC alphaRegPhos; SysPTM
T454SFDGNtLLNRGHPRD; SysPTM
S435LERNLsFEIKKPKC_alphaphosphoELM; SysPTM
S689SFVLAsEHNTPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S435LERNLsFEIKKPKC_groupphosphoELM; RegPhos; SysPTM
Y301KQLQLyEIHGAPhosphoSitePlus
T509NKVSVtPPEESPhosphoSitePlus; HPRD; phosphoELM
Y88SQDSDyINANFY_phosphatasePhosphoSitePlus
T587VDHDNtSPLFRHPRD; phosphoELM
S435LERNLsFEIKKPKACaRegPhos; SysPTM
Y64VKKNRyKDILPY_phosphatasePhosphoSitePlus
S507QSNKVsVTPPEPhosphoSitePlus
S324ENMVSsIEPEKPhosphoSitePlus; HPRD
S435LERNLsFEIKKPKA_groupphosphoELM; RegPhos; SysPTM
S435LERNLsFEIKKPRKCAHPRD; SysPTM
S435LERNLsFEIKKPhosphoSitePlus; phosphoELM; SysPTM
T573LTPSPtTQVETPhosphoSitePlus; HPRD; phosphoELM
S435LERNLsFEIKKPKCaRegPhos; SysPTM
S670KDVDVsEDSPPPhosphoSitePlus; HPRD
S596FRTPLsFTNPLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T318VNEINtENMVSPhosphoSitePlus
S39RLRRLsTKYRTPKA_groupphosphoELM; RegPhos
S39RLRRLsTKYRTPKACaRegPhos
S468KIKSAsPCIADPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T693ASEHNtPVRSEPhosphoSitePlus; HPRD; phosphoELM
S514TPPEEsQNSDTPhosphoSitePlus; HPRD; phosphoELM
S323TENMVsSIEPEPhosphoSitePlus
S517EESQNsDTPPRPhosphoSitePlus; HPRD; phosphoELM
T40LRRLStKYRTEPhosphoSitePlus
S39RLRRLsTKYRTPKCa(PKC alphaRegPhos
S39RLRRLsTKYRTPKC_alphaphosphoELM

Dephosphorylation site
PTN12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248594V313GCOSMICMelanoma19074898
ENSP00000248594T755ACOSMICOvarian Cancer21720365
ENSP00000248594E326DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000248594N317ICOSMICOvarian Cancer21720365
ENSP00000248594P772SCOSMICMelanoma19074898
ENSP00000248594E445DCOSMICPancreatic Cancer
ENSP00000248594H230YCOSMICBreast Cancer
ENSP00000248594D26ACOSMICOvarian Cancer21720365
ENSP00000248594K61ROMIM, HPIColorectal Cancer7509295
ENSP00000248594S483LCOSMICMelanoma19074898
ENSP00000248594E315DBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
PTN12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTN12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPTN12_HUMANkinase -> substrateRegPhos
KPCA_HUMANPTN12_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PTN12_HUMANFAK2_HUMANphosphatase -> substrateHPRD
PTN12_HUMANWASP_HUMANphosphatase -> substrateHPRD; NetPath
PTN12_HUMANABL1_HUMANphosphatase -> substrateHPRD
PTN12_HUMANFAK1_HUMANphosphatase -> substrateHPRD
PTN12_HUMANPPIP1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
PTN12_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0016311dephosphorylationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0002102podosomeIEAcellular_component
GO:0017124SH3 domain bindingIPImolecular_function
GO:0016791phosphatase activityIEAmolecular_function
GO:0042995cell projectionIEAcellular_component
GO:0006470protein dephosphorylationIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0004726non-membrane spanning protein tyrosine phosphataseTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006470protein dephosphorylationTASbiological_process
GO:0030054cell junctionIEAcellular_component


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