Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:XIAP_HUMAN
Description:X-linked inhibitor of apoptosis [Source:HGNC Symbol;Acc:592]
Location:chrX q25
Node attribute:substrate; ubiquitination(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S400EKIQIsGSNYKOrbi_VP5PhosphoSitePlus
T180DYAHLtPRELABIRPhosphoSitePlus
Y139ETHADyLLRTGPhosphoSitePlus
T32FNRLKtFANFPBIRPhosphoSitePlus
T356CLVRTtEKTPSHPRD
T355ECLVRtTEKTPHPRD
S87RHRKVsPNCRFPKB_groupphosphoELM
S123ENYLGsRDHFAPhosphoSitePlus
Y120YKVENyLGSRDPhosphoSitePlus
S87RHRKVsPNCRFAKT2HPRD
S87RHRKVsPNCRFAKT1HPRD
T429DESSQtSLQKEOrbi_VP5; DUF2039PhosphoSitePlus
T46PVSAStLARAGBIRPhosphoSitePlus
T470CGHLVtCKQCAHPRD
S40NFPSGsPVSASHPRD; phosphoELM
S436LQKEIsTEEQLHPRD
S45SPVSAsTLARABIRPhosphoSitePlus
S430ESSQTsLQKEIOrbi_VP5; DUF2039PhosphoSitePlus
S87RHRKVsPNCRFPKB_betaphosphoELM
Y404ISGSNyKSLEVOrbi_VP5PhosphoSitePlus
S87RHRKVsPNCRFBIRPhosphoSitePlus

Dephosphorylation site
XIAP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000395230L256VCOSMICLung Cancer
ENSP00000360242L256VCOSMICLung Cancer
ENSP00000360242H178RCOSMICOvarian Cancer21720365
ENSP00000395230C90YBIOMARTBreast Cancer21930507, 21930502
ENSP00000395230F462YCOSMICOvarian Cancer21720365
ENSP00000347858L256VCOSMICLung Cancer
ENSP00000347858C90YBIOMARTBreast Cancer21930507, 21930502
ENSP00000347858H178RCOSMICOvarian Cancer21720365
ENSP00000347858F462YCOSMICOvarian Cancer21720365
ENSP00000360242C90YBIOMARTBreast Cancer21930507, 21930502
ENSP00000360242F462YCOSMICOvarian Cancer21720365
ENSP00000395230H178RCOSMICOvarian Cancer21720365

Differential expressed protein
XIAP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
XIAP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT2_HUMANXIAP_HUMANkinase -> substrateHPRD; RegPhos
AKT1_HUMANXIAP_HUMANkinase -> substrateHPRD; RegPhos
FAK2_HUMANXIAP_HUMANkinase -> substrateRobert H Newman (2013)
TRI32_HUMANXIAP_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa04510Focal adhesion
hsa05222Small cell lung cancer
hsa05166HTLV-I infection
hsa04064NF-kappa B signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0070424regulation of nucleotide-binding oligomerization dTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0030510regulation of BMP signaling pathwayTASbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:0042127regulation of cell proliferationTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0055070copper ion homeostasisTASbiological_process
GO:0006974response to DNA damage stimulusIEPbiological_process
GO:0050727regulation of inflammatory responseTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0045088regulation of innate immune responseTASbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIDAmolecular_function


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