Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GDIB_HUMAN
Description:GDP dissociation inhibitor 2 [Source:HGNC Symbol;Acc:4227]
Location:chr10 p15.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y442KKNDIyGED__PhosphoSitePlus
S61FKIPGsPPESMGDIPhosphoSitePlus; SysPTM
Y5_MNEEyDVIVLGDIPhosphoSitePlus
Y203LDQPCyETINRHPRD; phosphoELM
Y111EGSFVyKGGKIHPRD
Y111EGSFVyKGGKIGDIPhosphoSitePlus
Y38MDRNPyYGGESGDIPhosphoSitePlus
T205QPCYEtINRIKGDIPhosphoSitePlus
S396DLGTEsQIFISGDIPhosphoSitePlus
Y203LDQPCyETINRGDIPhosphoSitePlus
Y93VKMLLyTEVTRGDIPhosphoSitePlus
Y245RLSAIyGGTYMGDIPhosphoSitePlus
Y197YRTDDyLDQPCHPRD
S61FKIPGsPPESMHPRD; phosphoELM; SysPTM
T394PKDLGtESQIFGDIPhosphoSitePlus
Y349AAQGKyIAIVSGDIPhosphoSitePlus
Y117KGGKIyKVPSTGDIPhosphoSitePlus
Y333RKSDIyVCMISGDIPhosphoSitePlus
S382EQKFVsISDLLGDIPhosphoSitePlus
S330QVNRKsDIYVCGDIPhosphoSitePlus
T122YKVPStEAEALGDIPhosphoSitePlus
Y224YGKSPyLYPLYGDIPhosphoSitePlus
T355IAIVStTVETKGDIPhosphoSitePlus
Y53PLEDLyKRFKIGDIPhosphoSitePlus
Y229YLYPLyGLGELGDIPhosphoSitePlus
S121IYKVPsTEAEAGDIPhosphoSitePlus
Y226KSPYLyPLYGLGDIPhosphoSitePlus
T94KMLLYtEVTRYGDIPhosphoSitePlus

Dephosphorylation site
GDIB_HUMAN do not have dephosphorylation site.

Mutation site
GDIB_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000369538Breast CancerNormal vs. CancertissueUp3.620005186
ENSP00000369538Breast CancerNormal vs. CancertissueUp4.920005186
ENSP00000369538Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000369538Breast CancerNormal vs. Cancercell lineUp1.720052998
ENSP00000369538Breast CancerMetastasiscell lineUp1.420052998
ENSP00000369538Breast CancerNormal vs. Cancercell lineUp1.520052998
ENSP00000369538Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000369538Breast CancerMetastasiscell lineDown0.7820052998
ENSP00000369538Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.3520858016
ENSP00000369538Biliary Tract CancerMetastasiscell lineUp319299076

Hyperphosphorylation site
GDIB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANGDIB_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANGDIB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
GDIB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005093Rab GDP-dissociation inhibitor activityIEAmolecular_function
GO:0005097Rab GTPase activator activityIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032851positive regulation of Rab GTPase activityIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmTAScellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process


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