Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYL9_HUMAN
Description:myosin, light chain 9, regulatory [Source:HGNC Symbol;Acc:15754]
Location:chr20 q11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S20PQRATsNVFAMEF_hand_5PhosphoSitePlus
T19RPQRAtSNVFADAPK3phosphoELM
Y143EVDEMyREAPIUPF0154; DUF1880; efhandPhosphoSitePlus
S60HDMLAsLGKNPEF_hand_5PhosphoSitePlus
S3___MSsKRAKAPhosphoSitePlus
S2____MsSKRAKPhosphoSitePlus
T19RPQRAtSNVFAEF_hand_5PhosphoSitePlus
S29AMFDQsQIQEFEF_hand_5PhosphoSitePlus
Y156KGNFNyVEFTREGFRphosphoELM
T10RAKAKtTKKRPPhosphoSitePlus
Y143EVDEMyREAPIEGFRphosphoELM
T19RPQRAtSNVFAHPRD; phosphoELM
Y156KGNFNyVEFTRDUF1880; efhandPhosphoSitePlus
S20PQRATsNVFAMDAPK3phosphoELM
S20PQRATsNVFAMHPRD; phosphoELM
T11AKAKTtKKRPQPhosphoSitePlus
T128LRELLtTMGDRUPF0154PhosphoSitePlus
S20PQRATsNVFAMPAK2phosphoELM

Dephosphorylation site
MYL9_HUMAN do not have dephosphorylation site.

Mutation site
MYL9_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000279022Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217
ENSP00000279022Breast CancerNormal vs. CancertissueDown0.5320739354
ENSP00000279022Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.6216807943
ENSP00000279022Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000279022Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000279022Uterine CancerNormal vs. CancertissueDown19771267

Hyperphosphorylation site
MYL9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMYL9_HUMANkinase -> substrateRegPhos
PAK2_HUMANMYL9_HUMANkinase -> substrateRegPhos
MYLK_HUMANMYL9_HUMANkinase -> substrateNetPath
DAPK3_HUMANMYL9_HUMANkinase -> substrateRegPhos
EGFR_HUMANMYL9_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04530Tight junction
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0030018Z discIEAcellular_component
GO:0016460myosin II complexIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005859muscle myosin complexTAScellular_component
GO:0001725stress fiberIEAcellular_component
GO:0008307structural constituent of muscleTASmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0006936muscle contractionTASbiological_process
GO:0006937regulation of muscle contractionTASbiological_process


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