| UniProt/SwissProt ID: | MYL9_HUMAN |
| Description: | myosin, light chain 9, regulatory [Source:HGNC Symbol;Acc:15754] |
| Location: | chr20 q11.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S20 | PQRATsNVFAM | EF_hand_5 | PhosphoSitePlus |
| T19 | RPQRAtSNVFA | DAPK3 | phosphoELM |
| Y143 | EVDEMyREAPI | UPF0154; DUF1880; efhand | PhosphoSitePlus |
| S60 | HDMLAsLGKNP | EF_hand_5 | PhosphoSitePlus |
| S3 | ___MSsKRAKA | PhosphoSitePlus | |
| S2 | ____MsSKRAK | PhosphoSitePlus | |
| T19 | RPQRAtSNVFA | EF_hand_5 | PhosphoSitePlus |
| S29 | AMFDQsQIQEF | EF_hand_5 | PhosphoSitePlus |
| Y156 | KGNFNyVEFTR | EGFR | phosphoELM |
| T10 | RAKAKtTKKRP | PhosphoSitePlus | |
| Y143 | EVDEMyREAPI | EGFR | phosphoELM |
| T19 | RPQRAtSNVFA | HPRD; phosphoELM | |
| Y156 | KGNFNyVEFTR | DUF1880; efhand | PhosphoSitePlus |
| S20 | PQRATsNVFAM | DAPK3 | phosphoELM |
| S20 | PQRATsNVFAM | HPRD; phosphoELM | |
| T11 | AKAKTtKKRPQ | PhosphoSitePlus | |
| T128 | LRELLtTMGDR | UPF0154 | PhosphoSitePlus |
| S20 | PQRATsNVFAM | PAK2 | phosphoELM |
| Dephosphorylation site |
| MYL9_HUMAN do not have dephosphorylation site. |
| Mutation site |
| MYL9_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000279022 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Up | 2 | 20804217 | ENSP00000279022 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.53 | 20739354 | ENSP00000279022 | Neoplasms by Histologic Type | Cancer vs. Cancer (subtype) | tissue | Down | 0.62 | 16807943 | ENSP00000279022 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2 | 15526344 | ENSP00000279022 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 16051329 | ENSP00000279022 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 19771267 |
| Hyperphosphorylation site |
| MYL9_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | MYL9_HUMAN | kinase -> substrate | RegPhos |
| PAK2_HUMAN | MYL9_HUMAN | kinase -> substrate | RegPhos |
| MYLK_HUMAN | MYL9_HUMAN | kinase -> substrate | NetPath |
| DAPK3_HUMAN | MYL9_HUMAN | kinase -> substrate | RegPhos |
| EGFR_HUMAN | MYL9_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04510 | Focal adhesion |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04530 | Tight junction |
| hsa04270 | Vascular smooth muscle contraction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0016460 | myosin II complex | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0005859 | muscle myosin complex | TAS | cellular_component |
| GO:0001725 | stress fiber | IEA | cellular_component |
| GO:0008307 | structural constituent of muscle | TAS | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0006937 | regulation of muscle contraction | TAS | biological_process |