| UniProt/SwissProt ID: | SCAM3_HUMAN |
| Description: | secretory carrier membrane protein 3 [Source:HGNC Symbol;Acc:10565] |
| Location: | chr1 q22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y83 | TEPKNyGSYST | PhosphoSitePlus; HPRD; RegPhos | |
| S85 | PKNYGsYSTQA | PhosphoSitePlus; HPRD | |
| S32 | IQHRPsRQYAT | PhosphoSitePlus; HPRD; SysPTM | |
| Y41 | ATLDVyNPFET | PhosphoSitePlus | |
| S87 | NYGSYsTQASA | PhosphoSitePlus | |
| Y41 | ATRDVyNPFET | EGFR | RegPhos |
| S76 | PSRKLsPTEPK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T78 | RKLSPtEPKNY | PhosphoSitePlus; HPRD | |
| T37 | SRQYAtLDVYN | PhosphoSitePlus | |
| Y86 | KNYGSySTQAS | PhosphoSitePlus; HPRD; RegPhos | |
| T52 | RKLSPtEPKNY | HPRD | |
| S91 | YSTQAsAAAAT | PhosphoSitePlus | |
| S50 | PSRKLsPTEPK | HPRD | |
| Y41 | ATRDVyNPFET | phosphoELM; RegPhos | |
| T88 | YGSYStQASAA | PhosphoSitePlus; HPRD | |
| Y60 | KNYGSySTQAS | HPRD | |
| S59 | PKNYGsYSTQA | HPRD | |
| T62 | YGSYStQASAA | HPRD | |
| Y57 | TEPKNyGSYST | HPRD | |
| Y35 | RPSRQyATRDV | phosphoELM; RegPhos | |
| Y41 | ATLDVyNPFET | EGFR | HPRD |
| Y35 | RPSRQyATLDV | PhosphoSitePlus; HPRD | |
| Y53 | EPPPAyEPPAP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T46 | YNPFEtREPPP | PhosphoSitePlus | |
| Dephosphorylation site |
| SCAM3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307275 | A184T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307275 | R5T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307275 | R329* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307275 | A25P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000307275 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.24 | 18646787 | ENSP00000307275 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.29 | 18646787 | ENSP00000307275 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.54 | 20739354 |
| Hyperphosphorylation site |
| SCAM3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | SCAM3_HUMAN | kinase -> substrate | RegPhos |
| EGFR_HUMAN | SCAM3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| SCAM3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006892 | post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0032526 | response to retinoic acid | IEA | biological_process |
| GO:0042221 | response to chemical stimulus | IEA | biological_process |
| GO:0000139 | Golgi membrane | IEA | cellular_component |