| UniProt/SwissProt ID: | GCFC2_HUMAN |
| Description: | GC-rich sequence DNA-binding factor 2 [Source:HGNC Symbol;Acc:1317] |
| Location: | chr2 p12 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S436 | DDELPsAEMID | HPRD | |
| S430 | QEGTSsDDELP | GCFC | PhosphoSitePlus |
| T192 | KRIPFtLRPQT | PhosphoSitePlus | |
| S106 | DKIHHsSESKD | PhosphoSitePlus | |
| S429 | HQEGTsSDDEL | GCFC | PhosphoSitePlus |
| S180 | EDDPEsEPDDH | PhosphoSitePlus; HPRD; phosphoELM | |
| S252 | CGNGSsKVKKF | PhosphoSitePlus | |
| S637 | VENKTsPHSKF | GCFC | PhosphoSitePlus |
| S109 | HHSSEsKDDQG | PhosphoSitePlus | |
| S217 | ETSEEsQEDEK | PhosphoSitePlus; HPRD; phosphoELM | |
| S40 | LPVPGsAEEEP | HPRD | |
| Y376 | KHESTyLQQLS | HPRD | |
| S174 | GMKREsEDDPE | PhosphoSitePlus; HPRD; phosphoELM | |
| S19 | ADSSDsDGAEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S251 | SCGNGsSKVKK | PhosphoSitePlus | |
| S262 | FDTSIsFPPVN | HPRD | |
| S430 | QEGTSsDDELP | HPRD; phosphoELM | |
| S214 | RNEETsEESQE | PhosphoSitePlus; HPRD; phosphoELM | |
| T428 | NHQEGtSSDDE | GCFC | PhosphoSitePlus |
| S16 | QRAADsSDSDG | PhosphoSitePlus; HPRD; phosphoELM | |
| S119 | GLSSDsSSSLG | HPRD | |
| S429 | HQEGTsSDDEL | HPRD; phosphoELM | |
| S246 | RDIDLsCGNGS | PhosphoSitePlus | |
| Y681 | KLLNRyLIIAL | GCFC | PhosphoSitePlus |
| T97 | TLDVStDEEDK | PhosphoSitePlus; HPRD; phosphoELM | |
| S17 | RAADSsDSDGA | PhosphoSitePlus; HPRD; phosphoELM | |
| T213 | SRNEEtSEESQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T259 | VKKFDtSISFP | HPRD | |
| T428 | NHQEGtSSDDE | HPRD; phosphoELM | |
| S96 | RTLDVsTDEED | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| GCFC2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318690 | Q229* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318690 | E108K | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| GCFC2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GCFC2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GCFC2_HUMAN | CAN2_HUMAN | TF -> target gene | TRANSFAC |
| GCFC2_HUMAN | EGFR_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| GCFC2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |