| UniProt/SwissProt ID: | AREG_HUMAN |
| Description: | amphiregulin [Source:HGNC Symbol;Acc:651] |
| Location: | chr4 q13.3 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y231 | QYVRKyEGEAE | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| AREG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| AREG_HUMAN do not have mutation site. |
| Differential expressed protein |
| AREG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AREG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AREG_HUMAN | EGFR_HUMAN | ligand -> receptor | HPMR |
| AREG_HUMAN | EGFR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04012 | ErbB signaling pathway |
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0045740 | positive regulation of DNA replication | IMP | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IDA | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |