Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPS15_HUMAN
Description:epidermal growth factor receptor pathway substrate 15 [Source:HGNC Symbol;Acc:3419]
Location:chr1 p32.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T663FFRQStDPFATPhosphoSitePlus
S562ESPARsSPELLPhosphoSitePlus; HPRD; phosphoELM
T779KIGTPtRPCPLPhosphoSitePlus
T777PPKIGtPTRPCPhosphoSitePlus; HPRD; phosphoELM
S467AELEEsVESGKPhosphoSitePlus; HPRD
S470EESVEsGKAQLPhosphoSitePlus; HPRD
S315PSDRAsLQKNIPhosphoSitePlus
S851FSAYPsEEDMIPhosphoSitePlus
S814FPGNDsPKEKDPhosphoSitePlus; HPRD; phosphoELM
Y443SQISTyEEELAPhosphoSitePlus
S323KNIIGsSPVADPhosphoSitePlus; HPRD; phosphoELM
S796INKLDsPDPFKPhosphoSitePlus; HPRD; phosphoELM
S324NIIGSsPVADFPhosphoSitePlus; HPRD; phosphoELM
S108FHDTSsPLLISPhosphoSitePlus; HPRD
S116LISGTsAAELPHPRD
S107RFHDTsSPLLIPhosphoSitePlus; HPRD
S741EDPFRsATSSSPhosphoSitePlus
S790PPGKRsINKLDPhosphoSitePlus; HPRD
S605PFNVDsSSLTGPhosphoSitePlus
S140IFDSLsPVNGFPhosphoSitePlus; HPRD; phosphoELM
S595DNNRHsKEEDPPhosphoSitePlus; HPRD; phosphoELM
S485QHLQDsQQEISPhosphoSitePlus; HPRD; phosphoELM
Y849ANFSAyPSEEDPhosphoSitePlus; phosphoELM
Y849ANFSAyPSEEDEGFRHPRD
S606FNVDSsSLTGPPhosphoSitePlus
S563SPARSsPELLPPhosphoSitePlus; phosphoELM

Dephosphorylation site
EPS15_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360798S622CCOSMICLung Cancer20668451

Differential expressed protein
EPS15_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPS15_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANEPS15_HUMANkinase -> substrateRegPhos
EGFR_HUMANEPS15_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0048268clathrin coat assemblyIDAbiological_process
GO:0030136clathrin-coated vesicleIEAcellular_component
GO:0031901early endosome membraneIEAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0060170cilium membraneIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0016050vesicle organizationTASbiological_process
GO:0005905coated pitTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005905coated pitIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006897endocytosisIEAbiological_process
GO:0030122AP-2 adaptor complexIEAcellular_component
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0032456endocytic recyclingICbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component


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