Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HBEGF_HUMAN
Description:heparin-binding EGF-like growth factor [Source:HGNC Symbol;Acc:3059]
Location:chr5 q31.3
Node attribute:PPI(target); ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S207LGMTNsH____PhosphoSitePlus
S6MKLLPsVVLKLPhosphoSitePlus
T37GLAAGtSNPDPPhosphoSitePlus
T44NPDPPtVSTDQPhosphoSitePlus
S38LAAGTsNPDPPPhosphoSitePlus

Dephosphorylation site
HBEGF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000230990K95NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
HBEGF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HBEGF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HBEGF_HUMANEGFR_HUMANligand -> receptorHPMR
HBEGF_HUMANEGFR_HUMANotherKEGG
ADA17_HUMANHBEGF_HUMANotherKEGG
ADA10_HUMANHBEGF_HUMANotherKEGG
MMP2_HUMANHBEGF_HUMANotherKEGG
HBEGF_HUMANERBB4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051549positive regulation of keratinocyte migrationIEAbiological_process
GO:0005615extracellular spaceISScellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0090303positive regulation of wound healingIMPbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIMPbiological_process
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0007517muscle organ developmentTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0051545negative regulation of elastin biosynthetic procesIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0008201heparin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0035313wound healing, spreading of epidermal cellsIEAbiological_process
GO:0008201heparin bindingIMPmolecular_function
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0008016regulation of heart contractionIEAbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0005887integral to plasma membraneISScellular_component
GO:0016477cell migrationIEAbiological_process


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