Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOS1_HUMAN
Description:son of sevenless homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:11187]
Location:chr2 p22.1
Node attribute:PPI(source); PPI(target); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y615IERLTyHMYADRasGEF_NPhosphoSitePlus
S1197YSPRYsISDRTErk2(MAPK1RegPhos
Y155RNIRHyEITKQHistonePhosphoSitePlus
S1167APAESsPSKIMPhosphoSitePlus
S1178SKHLDsPPAIPPhosphoSitePlus
S1132PHGPRsASVSSPhosphoSitePlus
S1043PGVRPsNPRPGPhosphoSitePlus; phosphoELM; RegPhos
T1257SPSPFtPPPPQPhosphoSitePlus
S1134GPRSAsVSSISPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1033PKKYSyPLKSPPhosphoSitePlus
S1265PPQTPsPHGTRPhosphoSitePlus
S1167APAESsPSKIMErk2RegPhos
S1275RRHLPsPPLTQPhosphoSitePlus; HPRD
S1193TSKAYsPRYSIErk2(MAPK1RegPhos
S1193TSKAYsPRYSIErk2RegPhos
S1166SAPAEsSPSKIPhosphoSitePlus
S1193TSKAYsPRYSIPhosphoSitePlus
S1210SDPPEsPPLLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1178SKHLDsPPAIPErk2(MAPK1RegPhos
S1132PHGPRsASVSSErk2(MAPK1RegPhos
S1197YSPRYsISDRTErk2RegPhos
S1193TSKAYsPRYSIMAPK1HPRD; phosphoELM
S1137SASVSsISLTKPhosphoSitePlus; HPRD; phosphoELM
S1082ASAPNsPRTPLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1252AFFPNsPSPFTPhosphoSitePlus
S1178SKHLDsPPAIPErk2RegPhos
Y618LTYHMyADPNFRasGEF_NPhosphoSitePlus
S1132PHGPRsASVSSMAPK1HPRD; phosphoELM
S802RAVQPsELVGSRasGEFPhosphoSitePlus
S1197YSPRYsISDRTMAPK1HPRD; phosphoELM
S1167APAESsPSKIMErk2(MAPK1RegPhos
Y1065PRKISySRIPEPhosphoSitePlus
T1298PPRQStSQHIPPhosphoSitePlus
S1167APAESsPSKIMMAPK1HPRD; phosphoELM
S1169AESSPsKIMSKPhosphoSitePlus
S1132PHGPRsASVSSErk2RegPhos
S1178SKHLDsPPAIPMAPK1HPRD; phosphoELM
S1299PRQSTsQHIPKPhosphoSitePlus
T1263PPPPQtPSPHGPhosphoSitePlus
S1297VPPRQsTSQHIPhosphoSitePlus
S1078TESTAsAPNSPPhosphoSitePlus; HPRD; RegPhos
S1161RRRPEsAPAESPhosphoSitePlus
S1197YSPRYsISDRTPhosphoSitePlus

Dephosphorylation site
SOS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387784H262RCOSMICBreast Cancer20668451
ENSP00000384675E433KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000384675L1231VCOSMICOvarian Cancer21720365
ENSP00000384675E815KCOSMICSkin Cancer21984974
ENSP00000387784P1183RCOSMICOvarian Cancer21720365
ENSP00000384675P1183RCOSMICOvarian Cancer21720365
ENSP00000384675M726ICOSMICSkin Cancer21984974
ENSP00000387784N233YCOSMICLung Cancer20668451
ENSP00000384675P1184HCOSMICOvarian Cancer21720365
ENSP00000384675N233YCOSMICLung Cancer20668451
ENSP00000384675E716QBIOMARTBreast Cancer21930507, 21930502
ENSP00000387784M726ICOSMICSkin Cancer21984974
ENSP00000387784L1231VCOSMICOvarian Cancer21720365
ENSP00000387784E13KCOSMICBreast Cancer20668451
ENSP00000387784E815KCOSMICSkin Cancer21984974
ENSP00000387784E716QBIOMARTBreast Cancer21930507, 21930502
ENSP00000384675E13KCOSMICBreast Cancer20668451
ENSP00000384675L450VCOSMICBreast Cancer20668451
ENSP00000387784E433KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000387784L450VCOSMICBreast Cancer20668451
ENSP00000387784P1184HCOSMICOvarian Cancer21720365
ENSP00000384675H262RCOSMICBreast Cancer20668451

Differential expressed protein
SOS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANSOS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANSOS1_HUMANkinase -> substrateRegPhos
GRB2_HUMANSOS1_HUMANotherKEGG
SOS1_HUMANRASH_HUMANotherKEGG
SOS1_HUMANRRAS2_HUMANotherKEGG
SOS1_HUMANGRP3_HUMANotherKEGG
EGFR_HUMANSOS1_HUMANotherKEGG
SOS1_HUMANGRP1_HUMANotherKEGG
SOS1_HUMANB2CL1_HUMANTF -> target geneKEGG
SOS1_HUMANSPY3_HUMANTF -> target geneKEGG
SOS1_HUMANMYC_HUMANTF -> target geneKEGG
SOS1_HUMANSPRE1_HUMANTF -> target geneKEGG
SOS1_HUMANCCND1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04540Gap junction
hsa05034Alcoholism
hsa04664Fc epsilon RI signaling pathway
hsa04062Chemokine signaling pathway
hsa05214Glioma
hsa05200Pathways in cancer
hsa05160Hepatitis C
hsa05221Acute myeloid leukemia
hsa04662B cell receptor signaling pathway
hsa04912GnRH signaling pathway
hsa04510Focal adhesion
hsa04722Neurotrophin signaling pathway
hsa05213Endometrial cancer
hsa05220Chronic myeloid leukemia
hsa04320Dorso-ventral axis formation
hsa04010MAPK signaling pathway
hsa04910Insulin signaling pathway
hsa05215Prostate cancer
hsa05223Non-small cell lung cancer
hsa05211Renal cell carcinoma
hsa04660T cell receptor signaling pathway
hsa04012ErbB signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04650Natural killer cell mediated cytotoxicity

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionNASbiological_process
GO:0005088Ras guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0032321positive regulation of Rho GTPase activityTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0003677DNA bindingIEAmolecular_function


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