| UniProt/SwissProt ID: | IPKA_HUMAN |
| Description: | protein kinase (cAMP-dependent, catalytic) inhibitor alpha [Source:HGNC Symbol;Acc:9017] |
| Location: | chr8 q21.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S59 | EDAQRsSTEQS | PKI | PhosphoSitePlus |
| Y8 | DVETTyADFIA | EGFR | HPRD; phosphoELM; RegPhos |
| Dephosphorylation site |
| IPKA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000336552 | G69R | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| IPKA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IPKA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EGFR_HUMAN | IPKA_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05034 | Alcoholism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004862 | cAMP-dependent protein kinase inhibitor activity | IEA | molecular_function |
| GO:0042308 | negative regulation of protein import into nucleus | IEA | biological_process |
| GO:0043086 | negative regulation of catalytic activity | IEA | biological_process |
| GO:0004862 | cAMP-dependent protein kinase inhibitor activity | TAS | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycl | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | IEA | biological_process |