Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AVR2B_HUMAN
Description:activin A receptor, type IIB [Source:HGNC Symbol;Acc:174]
Location:chr3 p22.2
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S490VNGTTsDCLVSPhosphoSitePlus
T488RSVNGtTSDCLPhosphoSitePlus

Dephosphorylation site
AVR2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340361L151FCOSMICSkin Cancer21984974
ENSP00000340361R482LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000340361Y31FTCGAOvarian Cancer21720365, 18772890
ENSP00000340361Y31FCOSMICOvarian Cancer21720365

Differential expressed protein
AVR2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AVR2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NODAL_HUMANAVR2B_HUMANligand -> receptorHPMR
LFTY2_HUMANAVR2B_HUMANligand -> receptorHPMR
AVR2B_HUMANKPCB_HUMANkinase -> substrateRobert H Newman (2013)
CDK16_HUMANAVR2B_HUMANkinase -> substrateRobert H Newman (2013)
AVR2B_HUMANTRI26_HUMANkinase -> substrateRobert H Newman (2013)
AVR2B_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
AVR2B_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
AVR2B_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001946lymphangiogenesisISSbiological_process
GO:0035265organ growthIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0032147activation of protein kinase activityIEAbiological_process
GO:0007498mesoderm developmentIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0001946lymphangiogenesisIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0060836lymphatic endothelial cell differentiationIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0004675transmembrane receptor protein serine/threonine kiIEAmolecular_function
GO:0061298retina vasculature development in camera-type eyeIEAbiological_process
GO:0032927positive regulation of activin receptor signaling IDAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0016362activin receptor activity, type IITASmolecular_function
GO:0019838growth factor bindingIPImolecular_function
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0060836lymphatic endothelial cell differentiationISSbiological_process
GO:0048185activin bindingIEAmolecular_function
GO:0060840artery developmentIEAbiological_process
GO:0048617embryonic foregut morphogenesisIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0004712protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0030073insulin secretionIEAbiological_process
GO:0060841venous blood vessel developmentISSbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0019838growth factor bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0001822kidney developmentIEAbiological_process
GO:0061298retina vasculature development in camera-type eyeISSbiological_process
GO:0009966regulation of signal transductionIEAbiological_process
GO:0031016pancreas developmentIEAbiological_process
GO:0060840artery developmentISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0001974blood vessel remodelingIEAbiological_process
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0060841venous blood vessel developmentIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionIDAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0007178transmembrane receptor protein serine/threonine kiTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0004674protein serine/threonine kinase activityIMPmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0001974blood vessel remodelingISSbiological_process
GO:0034711inhibin bindingIEAmolecular_function
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0009952anterior/posterior pattern specificationIMPbiological_process