Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UBE2N_HUMAN
Description:ubiquitin-conjugating enzyme E2N [Source:HGNC Symbol;Acc:12492]
Location:chr12 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T139AQAIEtARAWTUQ_conPhosphoSitePlus
Y34ESNARyFHVVIUQ_conPhosphoSitePlus
T144TARAWtRLYAMUQ_conPhosphoSitePlus
Y147AWTRLyAMNNIPhosphoSitePlus

Dephosphorylation site
UBE2N_HUMAN do not have dephosphorylation site.

Mutation site
UBE2N_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000316176Hepatocellular CarcinomaNormal vs. CancertissueUp4.315759316
ENSP00000316176Esophageal CancerNormal vs. CancertissueDown0.419142970
ENSP00000316176Breast CancerNormal vs. Cancercell lineDown0.4420052998
ENSP00000316176Breast CancerNormal vs. Cancercell lineUp1.320052998
ENSP00000316176Breast CancerMetastasiscell lineUp320052998
ENSP00000316176Breast CancerMetastasiscell lineDown0.3120198662
ENSP00000316176Oral CancerNormal vs. CancertissueDown0.3119691830
ENSP00000316176Pancreatic CancerNormal vs. CancertissueUp1819199705

Hyperphosphorylation site
UBE2N_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANUBE2N_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANUBE2N_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
UBE2N_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045739positive regulation of DNA repairIMPbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0006508proteolysisTASbiological_process
GO:0000724double-strand break repair via homologous recombinIMPbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0006464cellular protein modification processTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0033182regulation of histone ubiquitinationIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0031372UBC13-MMS2 complexIDAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0043130ubiquitin bindingIDAmolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0016881acid-amino acid ligase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000151ubiquitin ligase complexIDAcellular_component
GO:0000729DNA double-strand break processingIMPbiological_process
GO:0031058positive regulation of histone modificationIMPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0016567protein ubiquitinationTASbiological_process
GO:0050852T cell receptor signaling pathwayIMPbiological_process
GO:0006301postreplication repairIMPbiological_process
GO:0051443positive regulation of ubiquitin-protein ligase acIMPbiological_process
GO:0016574histone ubiquitinationIMPbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0035370UBC13-UEV1A complexIDAcellular_component
GO:0005737cytoplasmTAScellular_component
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0006282regulation of DNA repairTASbiological_process


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