| UniProt/SwissProt ID: | SF3B4_HUMAN |
| Description: | splicing factor 3b, subunit 4, 49kDa [Source:HGNC Symbol;Acc:10771] |
| Location: | chrHG1287_PATCH q21. |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y56 | GQHQGyGFVEF | RRM_1 | PhosphoSitePlus |
| S141 | PDTGNsKGYAF | HPRD | |
| Y69 | EEDADyAIKIM | RRM_1 | PhosphoSitePlus |
| Y16 | QDATVyVGGLD | HPRD; phosphoELM | |
| Y16 | QDATVyVGGLD | RRM_1 | PhosphoSitePlus |
| S141 | PDTGNsKGYAF | RRM_1 | PhosphoSitePlus |
| Y117 | DEKLLyDTFSA | HPRD | |
| Y56 | GQHQGyGFVEF | HPRD; phosphoELM | |
| Dephosphorylation site |
| SF3B4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271628 | P304S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SF3B4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SF3B4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAPK5_HUMAN | SF3B4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SF3B4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005681 | spliceosomal complex | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |