Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZEB2_HUMAN
Description:zinc finger E-box binding homeobox 2 [Source:HGNC Symbol;Acc:14881]
Location:chr2 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T285RKFKCtECGKAzf-C2H2PhosphoSitePlus
S731SLLPRsPVKPMPhosphoSitePlus
T254TFAYRtQLERHzf-C2H2PhosphoSitePlus
T782HSRSNtPSPLNPhosphoSitePlus; HPRD
S707NSRSPsLERSSPhosphoSitePlus
T470QIVDNtVSRQKPhosphoSitePlus
S1193HSMDDsSEDGKPhosphoSitePlus
S780LDHSRsNTPSPPhosphoSitePlus
S36VVDTGsETDEEPhosphoSitePlus
S305HLRIHsGEKPYPhosphoSitePlus
T837ATKNKtKASSIPhosphoSitePlus
S1203KMETKsDHEEDPhosphoSitePlus; HPRD
S843KASSIsLDHNSphosphoELM
S853SVSSSsENSDEphosphoELM
T38DTGSEtDEEDKPhosphoSitePlus
S1189ETGDHsMDDSSPhosphoSitePlus
Y147SDFEEyFAKRKPhosphoSitePlus
S703YQYSNsRSPSLPhosphoSitePlus
S324FSHSGsYSSHIzf-C2H2PhosphoSitePlus
S431LGVHPsAQSPMPhosphoSitePlus
S64ETSPAsVPNHEPhosphoSitePlus
S841KTKASsISLDHPhosphoSitePlus; phosphoELM
S778EKLDHsRSNTPPhosphoSitePlus
S360NSVSSsPTNSAPhosphoSitePlus
S327SGSYSsHISSKzf-C2H2PhosphoSitePlus
S796TSSKNsHSSSYPhosphoSitePlus
S840NKTKAsSISLDPhosphoSitePlus
S410ATHGFsGTSPFPhosphoSitePlus
T274QHQMLtQGAGNPhosphoSitePlus
S784RSNTPsPLNLSPhosphoSitePlus; HPRD
S819EPLDLsLPKQMPhosphoSitePlus
T1185RDEEEtGDHSMPhosphoSitePlus
S705YSNSRsPSLERPhosphoSitePlus
S848SLDHNsVSSSSphosphoELM
S1136PRDGEsEKEHEPhosphoSitePlus
S1194SMDDSsEDGKMPhosphoSitePlus
S829MKEPKsIIATKPhosphoSitePlus

Dephosphorylation site
ZEB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302501S305TCOSMICPancreatic Cancer21252315
ENSP00000302501P55HCOSMICPancreatic Cancer
ENSP00000386854D569EBIOMARTBreast Cancer21930507, 21930502
ENSP00000386854P55HCOSMICPancreatic Cancer
ENSP00000302501D86GCOSMICOvarian Cancer21720365
ENSP00000302501L226PCOSMICOvarian Cancer21720365
ENSP00000454157P55HCOSMICPancreatic Cancer
ENSP00000386854D86GCOSMICOvarian Cancer21720365
ENSP00000302501T915NCOSMICOvarian Cancer21720365
ENSP00000454157D396VCOSMICHead and Neck Cancer21798897
ENSP00000386854S305TCOSMICPancreatic Cancer21252315
ENSP00000454157P721SCOSMICSkin Cancer21984974
ENSP00000302501D569EBIOMARTBreast Cancer21930507, 21930502
ENSP00000386854D983NSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000386854P721SCOSMICSkin Cancer21984974
ENSP00000454157D983NCOSMICIntestines Cancer16959974
ENSP00000386854L226PCOSMICOvarian Cancer21720365
ENSP00000386854D396VCOSMICHead and Neck Cancer21798897
ENSP00000454157S305TCOSMICPancreatic Cancer21252315
ENSP00000302501D983NSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000386854T915NCOSMICOvarian Cancer21720365
ENSP00000454157L226PCOSMICOvarian Cancer21720365
ENSP00000386854R779KCOSMICOvarian Cancer21720365
ENSP00000302501D983NHPIColorectal Cancer16959974
ENSP00000302501P721SCOSMICSkin Cancer21984974
ENSP00000454157T915NCOSMICOvarian Cancer21720365
ENSP00000302501D396VCOSMICHead and Neck Cancer21798897
ENSP00000386854D983NHPIColorectal Cancer16959974
ENSP00000302501R779KCOSMICOvarian Cancer21720365
ENSP00000454157D86GCOSMICOvarian Cancer21720365
ENSP00000454157R779KCOSMICOvarian Cancer21720365

Differential expressed protein
ZEB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZEB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAPK5_HUMANZEB2_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANZEB2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANZEB2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ZEB2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007417central nervous system developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007399nervous system developmentNASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0046332SMAD bindingNASmolecular_function
GO:0021766hippocampus developmentIEAbiological_process
GO:0019208phosphatase regulator activityNASmolecular_function
GO:0030177positive regulation of Wnt receptor signaling pathIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0021846cell proliferation in forebrainIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0001756somitogenesisIEAbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0001843neural tube closureIEAbiological_process


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