| UniProt/SwissProt ID: | MK11_HUMAN |
| Description: | mitogen-activated protein kinase 11 [Source:HGNC Symbol;Acc:6873] |
| Location: | chr22 q13.33 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S243 | VVGTPsPEVLA | HPRD | |
| T180 | ADEEMtGYVAT | Pkinase | PhosphoSitePlus |
| Y182 | EEMTGyVATRW | Pkinase | PhosphoSitePlus |
| Y182 | EEMTGyVATRW | HPRD; phosphoELM | |
| S243 | VVGTPsPEVLA | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| MK11_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379113 | A221V | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000333685 | A221V | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| MK11_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MK11_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK11_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | MK11_HUMAN | kinase -> substrate | NetPath |
| MK11_HUMAN | MAPK5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK11_HUMAN | LZTS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | ATF2_HUMAN | kinase -> substrate | NetPath |
| MK11_HUMAN | HDBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | HNF4A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD |
| MK11_HUMAN | HIF1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04380 | Osteoclast differentiation |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05160 | Hepatitis C |
| hsa05133 | Pertussis |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05164 | Influenza A |
| hsa04912 | GnRH signaling pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04722 | Neurotrophin signaling pathway |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05140 | Leishmaniasis |
| hsa04010 | MAPK signaling pathway |
| hsa05132 | Salmonella infection |
| hsa05152 | Tuberculosis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04660 | T cell receptor signaling pathway |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa04370 | VEGF signaling pathway |
| hsa05131 | Shigellosis |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04728 | Dopaminergic synapse |
| hsa05145 | Toxoplasmosis |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0051090 | regulation of sequence-specific DNA binding transc | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0000187 | activation of MAPK activity | TAS | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0042692 | muscle cell differentiation | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0051149 | positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0004707 | MAP kinase activity | IDA | molecular_function |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |