Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK11_HUMAN
Description:mitogen-activated protein kinase 11 [Source:HGNC Symbol;Acc:6873]
Location:chr22 q13.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S243VVGTPsPEVLAHPRD
T180ADEEMtGYVATPkinasePhosphoSitePlus
Y182EEMTGyVATRWPkinasePhosphoSitePlus
Y182EEMTGyVATRWHPRD; phosphoELM
S243VVGTPsPEVLAPkinasePhosphoSitePlus

Dephosphorylation site
MK11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379113A221VGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000333685A221VGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
MK11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK11_HUMANBFAR_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANMK11_HUMANkinase -> substrateNetPath
MK11_HUMANMAPK5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK11_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANATF2_HUMANkinase -> substrateNetPath
MK11_HUMANHDBP1_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANHNF4A_HUMANkinase -> substrateRobert H Newman (2013)
MK11_HUMANEF2K_HUMANkinase -> substrateHPRD
MK11_HUMANHIF1A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa04621NOD-like receptor signaling pathway
hsa05160Hepatitis C
hsa05133Pertussis
hsa04622RIG-I-like receptor signaling pathway
hsa05164Influenza A
hsa04912GnRH signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa04010MAPK signaling pathway
hsa05132Salmonella infection
hsa05152Tuberculosis
hsa05169Epstein-Barr virus infection
hsa04660T cell receptor signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04664Fc epsilon RI signaling pathway
hsa04370VEGF signaling pathway
hsa05131Shigellosis
hsa04914Progesterone-mediated oocyte maturation
hsa04728Dopaminergic synapse
hsa05145Toxoplasmosis
hsa04723Retrograde endocannabinoid signaling
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0006950response to stressIDAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0042692muscle cell differentiationTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0004707MAP kinase activityIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0004707MAP kinase activityIDAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process


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