Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCE_HUMAN
Description:protein kinase C, epsilon [Source:HGNC Symbol;Acc:9401]
Location:chr2 p21
Node attribute:substrate; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T566GVTTTtFCGTPHPRD; phosphoELM
T710EEPVLtLVDEAautocatalysisRegPhos; SysPTM
S729EFKGFsYFGEDPRKCEHPRD; SysPTM
S316DKITNsGQRRKPhosphoSitePlus; HPRD; phosphoELM
T309ADLGVtPDKITPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T566GVTTTtFCGTPPkinasePhosphoSitePlus
S337PASGSsPSEEDPhosphoSitePlus; RegPhos
S339SGSSPsEEDRSPhosphoSitePlus; HPRD
T566GVTTTtFCGTPPDK-1phosphoELM
T314TPDKItNSGQRHPRD
S346EDRSKsAPTSPPhosphoSitePlus; HPRD
S344SEEDRsKSAPTPhosphoSitePlus
Y573CGTPDyIAPEIPkinasePhosphoSitePlus
S329IAGAEsPQPASPhosphoSitePlus; HPRD; SysPTM
T710EEPVLtLVDEAHPRD; phosphoELM; RegPhos; SysPTM
S350KSAPTsPCDQEPhosphoSitePlus; HPRD
S729EFKGFsYFGEDPKCeRegPhos; SysPTM
S334SPQPAsGSSPSPhosphoSitePlus; HPRD
S729EFKGFsYFGEDPKC_epsilonphosphoELM; SysPTM
T349SKSAPtSPCDQRegPhos
T703FDQDFtREEPVautocatalysisRegPhos
S380EHRAAsSPDGQHPRD
T703FDQDFtREEPVPKCeRegPhos
S388DGQLMsPGENGPhosphoSitePlus; HPRD
T710EEPVLtLVDEAPkinase_CPhosphoSitePlus; SysPTM
S729EFKGFsYFGEDPkinase_CPhosphoSitePlus; SysPTM
Y434GKDEVyAVKVLPkinasePhosphoSitePlus
S729EFKGFsYFGEDPKCe(PKC epsilonRegPhos; SysPTM
S368IRKALsFDNRGPhosphoSitePlus; HPRD; SysPTM
S234PDQVGsQRFSVPhosphoSitePlus
T703FDQDFtREEPVPRKCEHPRD
T566GVTTTtFCGTPPDPK1HPRD
S729EFKGFsYFGEDautocatalysisRegPhos; SysPTM
T228LKKQEtPDQVGPhosphoSitePlus; HPRD; SysPTM
S729EFKGFsYFGEDHPRD; phosphoELM; SysPTM
T181YLRQPtYCSHCC1_1PhosphoSitePlus
T566GVTTTtFCGTPPDK1RegPhos
S336QPASGsSPSEEHPRD

Dephosphorylation site
KPCE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306124Q197PTCGAOvarian Cancer21720365, 18772890
ENSP00000306124E143KSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000306124E143KBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000306124R372QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000306124R150HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000306124E659QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
KPCE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCE_HUMANPP14A_HUMANkinase -> substrateHPRD
KPCE_HUMANTRPV1_HUMANkinase -> substrateHPRD
KPCE_HUMANB3A3_HUMANkinase -> substrateHPRD
KPCE_HUMANKPCE_HUMANkinase -> substrateHPRD
KPCE_HUMANDCE1_HUMANkinase -> substrateHPRD
KPCE_HUMANTRAF2_HUMANkinase -> substrateNetPath
KPCE_HUMANOPRD_HUMANkinase -> substrateHPRD
PDPK1_HUMANKPCE_HUMANkinase -> substrateHPRD; RegPhos
KPCE_HUMANADAP1_HUMANkinase -> substrateHPRD
KPCE_HUMANK1C18_HUMANkinase -> substrateHPRD
KPCE_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCE_HUMANGRM5_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKPCE_HUMANkinase -> substrateRegPhos
CASP7_HUMANKPCE_HUMANotherNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa04666Fc gamma R-mediated phagocytosis
hsa04930Type II diabetes mellitus
hsa04530Tight junction
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007049cell cycleIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0035669TRAM-dependent toll-like receptor 4 signaling pathIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008047enzyme activator activityIMPmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0071944cell peripheryIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:2000273positive regulation of receptor activityIEAbiological_process
GO:0032230positive regulation of synaptic transmission, GABAIEAbiological_process
GO:0030546receptor activator activityIEAmolecular_function
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0035641locomotory exploration behaviorIEAbiological_process
GO:0002281macrophage activation involved in immune responseIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0050996positive regulation of lipid catabolic processIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0061178regulation of insulin secretion involved in cellulIEAbiological_process
GO:0010763positive regulation of fibroblast migrationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005783endoplasmic reticulumIDAcellular_component
GO:2001031positive regulation of cellular glucuronidationIMPbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0003785actin monomer bindingIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0071361cellular response to ethanolIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0035276ethanol bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0005829cytosolIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0090303positive regulation of wound healingIMPbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0070257positive regulation of mucus secretionIEAbiological_process
GO:0004699calcium-independent protein kinase C activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0004697protein kinase C activityIDAmolecular_function
GO:0010634positive regulation of epithelial cell migrationIMPbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0010811positive regulation of cell-substrate adhesionIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:007188914-3-3 protein bindingIEAmolecular_function