Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PKN2_HUMAN
Description:protein kinase N2 [Source:HGNC Symbol;Acc:9406]
Location:chr1 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y676VLLAEyKNTNEPkinasePhosphoSitePlus
S631PDTPQsGLEYSPhosphoSitePlus; HPRD; phosphoELM
Y624KSQSEyKPDTPPhosphoSitePlus
T364WSPSEtRSSFMHPRD
T951FDDEFtSEAPIPDPK1HPRD
T304VAASPtLSPRQPhosphoSitePlus; HPRD; phosphoELM
T121TDCPRtPDTPNHPRD; phosphoELM
S264ARFNEsSQKLDHR1PhosphoSitePlus
Y810KEGMGyGDRTSPkinasePhosphoSitePlus
T958EAPILtPPREPPkinase_CPhosphoSitePlus
T124PRTPDtPNNDPRP-C_CPhosphoSitePlus
T816GDRTStFCGTPPDHK1RegPhos
S362PGWSPsETRSSPhosphoSitePlus; HPRD; phosphoELM
T121TDCPRtPDTPNRP-C_CPhosphoSitePlus
S701RDEVDsLMCEKPkinasePhosphoSitePlus
S583PPRASsLGEIDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S255DRKALsEAQARHPRD
S636SGLEYsGIQELPhosphoSitePlus
S535HSGTFsPQAPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S110AHIVVsDPEDIRP-C_C; HR1PhosphoSitePlus
S367SETRSsFMSRTHPRD; phosphoELM
S531PTVNHsGTFSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T628EYKPDtPQSGLPhosphoSitePlus; HPRD; phosphoELM
S582APPRAsSLGEIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T816GDRTStFCGTPPDPK1HPRD
T124PRTPDtPNNDPHPRD; phosphoELM
S349NVPGRsKATSVPhosphoSitePlus
S559LAPPAsDSTVTPhosphoSitePlus; phosphoELM; RegPhos
S289KNHPKsRIIIEHR1PhosphoSitePlus
T533VNHSGtFSPQAPhosphoSitePlus; HPRD; phosphoELM
S815YGDRTsTFCGTPkinasePhosphoSitePlus
S416PISNQsWDQKFPhosphoSitePlus
T816GDRTStFCGTPHPRD; phosphoELM; RegPhos
T816GDRTStFCGTPPDK1HPRD; RegPhos
T820STFCGtPEFLAHPRD; phosphoELM
T527RRAIPtVNHSGHPRD
S408VVGQTsWKPISPhosphoSitePlus
T958EAPILtPPREPHPRD; phosphoELM; RegPhos
S255DRKALsEAQARHR1PhosphoSitePlus
S615QNDRNsILPKSPhosphoSitePlus; HPRD
S302SLVAAsPTLSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S274DLLKYsLEQRLHR1PhosphoSitePlus
S360ALPGWsPSETRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S110AHIVVsDPEDIHPRD; phosphoELM
S306ASPTLsPRQSMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T816GDRTStFCGTPPDK-1phosphoELM
T516NINIAtWGRLVPhosphoSitePlus
S646LEDRRsQQRFQPhosphoSitePlus
Y635QSGLEySGIQEPhosphoSitePlus; HPRD; phosphoELM
T951FDDEFtSEAPIPDK1HPRD; RegPhos
T816GDRTStFCGTPPkinasePhosphoSitePlus
S289KNHPKsRIIIEHPRD; phosphoELM; RegPhos
T814GYGDRtSTFCGPkinasePhosphoSitePlus
Y273LDLLKySLEQRHR1PhosphoSitePlus
T951FDDEFtSEAPIPDHK1RegPhos
S413SWKPIsNQSWDPhosphoSitePlus
T820STFCGtPEFLAPkinasePhosphoSitePlus
S370RSSFMsRTSKSHPRD
S561PPASDsTVTKLPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
PKN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359552R523TBIOMARTBreast Cancer21930507, 21930502
ENSP00000359552R940*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000359552G65RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PKN2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PKN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANPKN2_HUMANkinase -> substrateRegPhos
PDK1_HUMANPKN2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPKN2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityTASmolecular_function
GO:0004697protein kinase C activityIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0032154cleavage furrowIDAcellular_component
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0043296apical junction complexIEAcellular_component
GO:0043297apical junction assemblyIMPbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043296apical junction complexIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0030496midbodyIDAcellular_component
GO:2000145regulation of cell motilityIMPbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0042826histone deacetylase bindingIDAmolecular_function
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0010631epithelial cell migrationIDAbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0043297apical junction assemblyIEAbiological_process


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