Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NIPBL_HUMAN
Description:Nipped-B homolog (Drosophila) [Source:HGNC Symbol;Acc:28862]
Location:chr5 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1096DEDNDsDEAFEPhosphoSitePlus; HPRD; phosphoELM
S1152RNRSPsDSDMEPhosphoSitePlus; HPRD; phosphoELM
T145SNYQQtTISHSPhosphoSitePlus
S1992ESLADsDNKGVPhosphoSitePlus
Y345EKAAMyDIISSPhosphoSitePlus
S103AVLARsPNVFRPhosphoSitePlus
S182PYAPQsPAGYMPhosphoSitePlus; HPRD; phosphoELM
S768DNRRDsGKPSTPhosphoSitePlus
T359DSTKLtLRLSRPhosphoSitePlus
S299PLILQsQSLPCPhosphoSitePlus
S2490SKENEsSDSEEPhosphoSitePlus; HPRD
S352IISSPsKDSTKPhosphoSitePlus
S1154RSPSDsDMEDYPhosphoSitePlus; HPRD; phosphoELM
S2658LLGGGsPKNNTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y1146SGGGRyRNRSPPhosphoSitePlus
S849ETLRSsSRNEHHPRD; phosphoELM
S284CSPAGsEGTPKPhosphoSitePlus; HPRD; phosphoELM
T160FVPPQtSSGNRHPRD
S2613EEVKRsIVKQYPhosphoSitePlus
T914GFKSPtSKDDKHPRD
S2682RGGGTsGSLRRPhosphoSitePlus
S1988LKYEEsLADSDPhosphoSitePlus
T1733RSIIKtTPSQFPhosphoSitePlus; HPRD
S591VGSLKsTPENHPhosphoSitePlus
S912KLGFKsPTSKDPhosphoSitePlus; HPRD; phosphoELM
T702KSRPEtPKQKGPhosphoSitePlus
S609SDPELsKSEMKPhosphoSitePlus; HPRD
S208QASVSsPIVAGHPRD; phosphoELM
S136NSMHSsPASSNHPRD; phosphoELM
T592GSLKStPENHPPhosphoSitePlus
T406SKTPItPQDINPhosphoSitePlus
T1439AIKLVtAVFSRPhosphoSitePlus; HPRD
S2493NESSDsEEEVSPhosphoSitePlus; HPRD
S318DILLDsPERKQPhosphoSitePlus; HPRD; phosphoELM
S874KHRHEsGDSREPhosphoSitePlus; HPRD; phosphoELM
S269MRNAAsFPLRSPhosphoSitePlus
S280PQPVCsPAGSEPhosphoSitePlus; HPRD; phosphoELM
S790DTKSDsPRLKSPhosphoSitePlus
T558SQASItQDSDSPhosphoSitePlus
S349MYDIIsSPSKDPhosphoSitePlus
S139HSSPAsSNYQQHPRD; phosphoELM
S2511RVDSDsDSDSEPhosphoSitePlus; HPRD; phosphoELM
S306SLPCSsPRDVPPhosphoSitePlus; HPRD; phosphoELM
S2491KENESsDSEEEPhosphoSitePlus; HPRD
T735DGRPEtPKQKGPhosphoSitePlus
Y1159SDMEDySPPPSHPRD; phosphoELM
S274SFPLRsPQPVCPhosphoSitePlus; phosphoELM
S1736IKTTPsQFSTLPhosphoSitePlus
T746ESRPEtPKQKNPhosphoSitePlus
S262DDGDSsTMRNAPhosphoSitePlus
S305QSLPCsSPRDVPhosphoSitePlus; HPRD; phosphoELM
T2681DRGGGtSGSLRPhosphoSitePlus
T403GQTSKtPITPQPhosphoSitePlus
S1090YAEISsDEDNDPhosphoSitePlus; HPRD; phosphoELM
S1089KYAEIsSDEDNPhosphoSitePlus; HPRD; phosphoELM
S1009VLQKLsLDDVQPhosphoSitePlus
T2765VPWVDtIKESDPhosphoSitePlus
S553AGRVDsQASITPhosphoSitePlus; HPRD
S2498SEEEVsRPRKSPhosphoSitePlus
S556VDSQAsITQDSPhosphoSitePlus; HPRD
S350YDIISsPSKDSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T287AGSEGtPKGSRPhosphoSitePlus; phosphoELM
S162PPQTSsGNRFMPhosphoSitePlus; HPRD; phosphoELM
S368SRVRSsDMDQQPhosphoSitePlus; HPRD
S378QEDMIsGVENSPhosphoSitePlus; HPRD
T1198MMDSStFKRFTPhosphoSitePlus
T2190DEEVQtKAIIGPhosphoSitePlus
S877HESGDsRERPSPhosphoSitePlus; HPRD; phosphoELM
S579NDAPVsVLQEDPhosphoSitePlus
S2509RKRVDsDSDSDPhosphoSitePlus; HPRD; phosphoELM
S367LSRVRsSDMDQPhosphoSitePlus; HPRD; phosphoELM
S148QQTTIsHSPSSPhosphoSitePlus; HPRD
S301ILQSQsLPCSSPhosphoSitePlus
S135QNSMHsSPASSHPRD
T599ENHPEtPKKKSPhosphoSitePlus
T713ESRPEtPKQKSPhosphoSitePlus; HPRD; phosphoELM
S150TTISHsPSSRFPhosphoSitePlus; HPRD; phosphoELM
S1125RDRRSsGDHRRPhosphoSitePlus
S1150RYRNRsPSDSDPhosphoSitePlus; HPRD; phosphoELM
S172MPQQNsPVPSPPhosphoSitePlus; HPRD; phosphoELM
S2515DSDSDsEDDINPhosphoSitePlus; HPRD; phosphoELM
S616SEMKQsESRLAPhosphoSitePlus; HPRD
S1160DMEDYsPPPSLPhosphoSitePlus; HPRD; phosphoELM
S1077NKRKRsTVNEKPhosphoSitePlus
T724DGHPEtPKQKGPhosphoSitePlus
S892KSRPDsPRVKQPhosphoSitePlus; HPRD
Y1985EHILKyEESLAPhosphoSitePlus
T757EGRPEtPKHRHPhosphoSitePlus; HPRD
T646ETKVEtQTEELPhosphoSitePlus; HPRD; phosphoELM
T1533TNSYEtAMRTAHPRD
S2672TEDDEsDGEDRPhosphoSitePlus; HPRD; phosphoELM
T1734SIIKTtPSQFSHPRD
S363LTLRLsRVRSSPhosphoSitePlus
Y1085NEKPKyAEISSHPRD
S2684GGTSGsLRRSKPhosphoSitePlus
Y247GSSEDyLHMVHPhosphoSitePlus
S1042KSNKGsIDQSVPhosphoSitePlus
S2652NKAITsLLGGGPhosphoSitePlus; HPRD
S255MVHRLsSDDGDPhosphoSitePlus
S850TLRSSsRNEHGHPRD; phosphoELM
Y1531VITNSyETAMRHPRD
S256VHRLSsDDGDSPhosphoSitePlus; HPRD; phosphoELM
S709KQKGEsRPETPPhosphoSitePlus; HPRD
S2513DSDSDsDSEDDPhosphoSitePlus; HPRD; phosphoELM
S1609ALRVAsLDYLGPhosphoSitePlus; HPRD
T2667NTAAEtEDDESPhosphoSitePlus; HPRD; phosphoELM
Y126MMMSQyKLSQNPhosphoSitePlus

Dephosphorylation site
NIPBL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282516D1646GCOSMICOvarian Cancer21720365
ENSP00000282516L2237FCOSMICSkin Cancer21984974
ENSP00000282516S861*COSMICOvarian Cancer21720365
ENSP00000282516T1918ACOSMICOvarian Cancer21720365
ENSP00000282516G519RCOSMICSkin Cancer21984974
ENSP00000406266M264VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000406266T1918ATCGAOvarian Cancer21720365, 18772890
ENSP00000406266K1690RTCGAOvarian Cancer21720365, 18772890
ENSP00000282516P1151SCOSMICSkin Cancer21984974
ENSP00000406266S861*TCGAOvarian Cancer21720365, 18772890
ENSP00000406266S349GTCGAOvarian Cancer21720365, 18772890
ENSP00000282516P288TCOSMICOvarian Cancer20826764
ENSP00000282516R1941TBIOMARTBreast Cancer21930507, 21930502
ENSP00000282516S525CCOSMICHead and Neck Cancer21798893
ENSP00000282516S349GCOSMICOvarian Cancer21720365
ENSP00000406266D1646GTCGAOvarian Cancer21720365, 18772890
ENSP00000282516R2582*BIOMARTBreast Cancer21930507, 21930502
ENSP00000282516S1258LCOSMICHepatocellular Carcinoma21822264
ENSP00000282516M264VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000406266R1941TBIOMARTBreast Cancer21930507, 21930502
ENSP00000282516K1690RCOSMICOvarian Cancer21720365
ENSP00000406266R2582*BIOMARTBreast Cancer21930507, 21930502
ENSP00000282516E1647KSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
NIPBL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NIPBL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANNIPBL_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANNIPBL_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NIPBL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060325face morphogenesisIMPbiological_process
GO:0019827stem cell maintenanceIEAbiological_process
GO:0071481cellular response to X-rayIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0034088maintenance of mitotic sister chromatid cohesionIMPbiological_process
GO:0001656metanephros developmentNASbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0050890cognitionIMPbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0045995regulation of embryonic developmentIMPbiological_process
GO:0042634regulation of hair cycleIMPbiological_process
GO:0045778positive regulation of ossificationIEAbiological_process
GO:0061038uterus morphogenesisIMPbiological_process
GO:0032116SMC loading complexIDAcellular_component
GO:0048557embryonic digestive tract morphogenesisIMPbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0048638regulation of developmental growthIMPbiological_process
GO:0070087chromo shadow domain bindingIPImolecular_function
GO:0007420brain developmentIMPbiological_process
GO:0042471ear morphogenesisIMPbiological_process
GO:0048592eye morphogenesisIMPbiological_process
GO:0003007heart morphogenesisIMPbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0035261external genitalia morphogenesisIMPbiological_process
GO:0031065positive regulation of histone deacetylationIDAbiological_process
GO:0007064mitotic sister chromatid cohesionIMPbiological_process
GO:0048703embryonic viscerocranium morphogenesisIEAbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0035136forelimb morphogenesisIMPbiological_process
GO:0003151outflow tract morphogenesisIMPbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0048589developmental growthIMPbiological_process
GO:0034613cellular protein localizationIMPbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0035115embryonic forelimb morphogenesisIMPbiological_process
GO:0036033mediator complex bindingIEAmolecular_function
GO:0061010gall bladder developmentIMPbiological_process
GO:0007605sensory perception of soundIMPbiological_process