Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AKT2_HUMAN
Description:v-akt murine thymoma viral oncogene homolog 2 [Source:HGNC Symbol;Acc:392]
Location:chr19 q13.2
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S478FSYSAsIRERegPhos
Y438EVDTRyFDDEFPkinase_CPhosphoSitePlus
S474HFPQFsYSASIPkinase_CPhosphoSitePlus
T451QSITItPPDRYHPRD; phosphoELM; RegPhos
S447EFTAQsITITPPkinase_CPhosphoSitePlus
Y456TPPDRyDSLGLPkinase_CPhosphoSitePlus
Y177KATGRyYAMKIPkinasePhosphoSitePlus
S476PQFSYsASIHPRD
S474HFPQFsYSASIPDK1RegPhos
S478FSYSAsIHPRD
S478FSYSAsIRE__Pkinase_CPhosphoSitePlus
S474HFPQFsYSASIPDPK1HPRD
S379SPEAKsLLAGLPkinasePhosphoSitePlus
T313KTFCGtPEYLAPkinasePhosphoSitePlus
S458PDRYDsLGLLEPkinase_CPhosphoSitePlus
T309GATMKtFCGTPPkinasePhosphoSitePlus
Y327LEDNDyGRAVDPkinasePhosphoSitePlus
T449TAQSItITPPDPkinase_CPhosphoSitePlus
T451QSITItPPDRYPkinase_CPhosphoSitePlus
Y316CGTPEyLAPEVPkinasePhosphoSitePlus
S242LFFHLsRERVFPkinasePhosphoSitePlus
S474HFPQFsYSASIHPRD; phosphoELM; RegPhos
S476PQFSYsASIRERegPhos
T81RCLQWtTVIERPHPhosphoSitePlus
S476PQFSYsASIREPkinase_CPhosphoSitePlus
S126DYKCGsPSDSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T306ISDGAtMKTFCPkinasePhosphoSitePlus
T309GATMKtFCGTPPDPK1HPRD
Y178ATGRYyAMKILPkinasePhosphoSitePlus
T309GATMKtFCGTPPDK-1phosphoELM
T309GATMKtFCGTPPDK1RegPhos
S302CKEGIsDGATMPkinasePhosphoSitePlus
Y38GSFIGyKERPEPHPhosphoSitePlus
Y475FPQFSySASIRPkinase_CPhosphoSitePlus

Dephosphorylation site
AKT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399532E17KBIOMARTBreast Cancer21930507, 21930502
ENSP00000375892E17KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
AKT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S474Pkinase_CRTHFPQFsYSASIREovarian cancer10822383PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AKT2_HUMANIKKA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
AKT2_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
AKT2_HUMANAKTS1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANAKT2_HUMANkinase -> substrateRegPhos
AKT2_HUMANFOXO4_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANAKT2_HUMANkinase -> substrateRegPhos
AKT2_HUMANXIAP_HUMANkinase -> substrateHPRD; RegPhos
MYOD1_HUMANAKT2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa04370VEGF signaling pathway
hsa04910Insulin signaling pathway
hsa05215Prostate cancer
hsa04012ErbB signaling pathway
hsa05162Measles
hsa04722Neurotrophin signaling pathway
hsa05160Hepatitis C
hsa04150mTOR signaling pathway
hsa04380Osteoclast differentiation
hsa05145Toxoplasmosis
hsa04010MAPK signaling pathway
hsa04973Carbohydrate digestion and absorption
hsa05164Influenza A
hsa04914Progesterone-mediated oocyte maturation
hsa05222Small cell lung cancer
hsa05218Melanoma
hsa04920Adipocytokine signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05166HTLV-I infection
hsa05223Non-small cell lung cancer
hsa04620Toll-like receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa05212Pancreatic cancer
hsa04530Tight junction
hsa05214Glioma
hsa05210Colorectal cancer
hsa04660T cell receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05169Epstein-Barr virus infection
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa05152Tuberculosis
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa04510Focal adhesion
hsa05221Acute myeloid leukemia
hsa05142Chagas disease (American trypanosomiasis)
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032587ruffle membraneISScellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0071156regulation of cell cycle arrestTASbiological_process
GO:0031340positive regulation of vesicle fusionISSbiological_process
GO:0010907positive regulation of glucose metabolic processIMPbiological_process
GO:2001275positive regulation of glucose import in response IEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005978glycogen biosynthetic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0008643carbohydrate transportIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0045725positive regulation of glycogen biosynthetic proceIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0090314positive regulation of protein targeting to membraISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0065002intracellular protein transmembrane transportISSbiological_process
GO:0045444fat cell differentiationTASbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0072659protein localization to plasma membraneIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030334regulation of cell migrationTASbiological_process
GO:0006464cellular protein modification processTASbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0005938cell cortexISScellular_component
GO:0046326positive regulation of glucose importIMPbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:2000147positive regulation of cell motilityIMPbiological_process
GO:0016301kinase activityTASmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0032859activation of Ral GTPase activityIEAbiological_process
GO:0032000positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0060644mammary gland epithelial cell differentiationTASbiological_process
GO:0032287peripheral nervous system myelin maintenanceIEAbiological_process
GO:0001934positive regulation of protein phosphorylationISSbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0010748negative regulation of plasma membrane long-chain IMPbiological_process
GO:0005886plasma membraneISScellular_component