Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VIGLN_HUMAN
Description:high density lipoprotein binding protein [Source:HGNC Symbol;Acc:4857]
Location:chr2 q37.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T671NSLIGtKGRLIHPRD
S667AKLHNsLIGTKKH_1PhosphoSitePlus
S1223EAKAPsRGFVVPhosphoSitePlus; HPRD; phosphoELM
S904ITRDFsVQIKFKH_1PhosphoSitePlus
S31VATLNsEEESDPhosphoSitePlus; HPRD; phosphoELM
S368SFTVSsVAAPSKH_1PhosphoSitePlus
T671NSLIGtKGRLIKH_1PhosphoSitePlus
S944DCDPGsPRRCDHPRD; phosphoELM
S944DCDPGsPRRCDKH_1PhosphoSitePlus
Y40SDPPTyKDAFPPhosphoSitePlus
Y465RIKDQyKVSVRKH_1PhosphoSitePlus
S1252SEEFPsFGAQVPhosphoSitePlus; HPRD
T1058FKLSVtVDPKYHPRD
T296KKKKTtTIAVEPhosphoSitePlus
T111EIMQRtGAHLEPhosphoSitePlus
T1058FKLSVtVDPKYKH_1PhosphoSitePlus
S1236APWTAsSSEKAHPRD; phosphoELM
S454HLIGKsGANINKH_1PhosphoSitePlus
Y582LVENSySISVPPhosphoSitePlus
S1237PWTASsSEKAPHPRD; phosphoELM
S468DQYKVsVRIPPKH_1PhosphoSitePlus
S645RSRILsIQKDLPhosphoSitePlus
S1056RSFKLsVTVDPKH_1PhosphoSitePlus
Y437INRMDyVEINIHPRD; phosphoELM
T297KKKTTtIAVEVKH_1PhosphoSitePlus
S1246APDMSsSEEFPPhosphoSitePlus
Y437INRMDyVEINIKH_1PhosphoSitePlus
S583VENSYsISVPIKH_1PhosphoSitePlus
S581DLVENsYSISVPhosphoSitePlus
S126KDQGLsIMVSGHPRD
Y1210EALQVyMKPPAPhosphoSitePlus
S216EVLLIsAEQDKPhosphoSitePlus; HPRD
Y358ALTEVyAKANSPhosphoSitePlus
S756RKVRDsTGARVHPRD
T1261QVAPKtLPWGPPhosphoSitePlus; HPRD
S1056RSFKLsVTVDPHPRD

Dephosphorylation site
VIGLN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375837D939VSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000312042E203QBIOMARTBreast Cancer21930507, 21930502
ENSP00000375836G778ECOSMICSkin Cancer21984974
ENSP00000375837A1140TCOSMICHead and Neck Cancer21798893
ENSP00000312042A1140TCOSMICHead and Neck Cancer21798893
ENSP00000375836D939VSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000375837E203QBIOMARTBreast Cancer21930507, 21930502
ENSP00000312042D939VSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000375836E203QBIOMARTBreast Cancer21930507, 21930502
ENSP00000312042K568NSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000375836A1140TCOSMICHead and Neck Cancer21798893
ENSP00000375836K568NSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000312042G778ECOSMICSkin Cancer21984974
ENSP00000375837G778ECOSMICSkin Cancer21984974
ENSP00000375837K568NSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000312042Hepatocellular CarcinomaNormal vs. Cancercell lineUp218646787
ENSP00000312042Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.5316319398
ENSP00000312042Hepatocellular CarcinomaMetastasiscell lineUp1.819016532
ENSP00000312042Breast CancerNormal vs. CancertissueUp0.4520739354
ENSP00000312042Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496

Hyperphosphorylation site
VIGLN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANVIGLN_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANVIGLN_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
VIGLN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0006869lipid transportIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008289lipid bindingTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0034364high-density lipoprotein particleIEAcellular_component
GO:0005737cytoplasmIDAcellular_component


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