| UniProt/SwissProt ID: | CD22_HUMAN |
| Description: | CD22 molecule [Source:HGNC Symbol;Acc:1643] |
| Location: | chr19 q13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y842 | QENVDyVIL | phosphoELM | |
| Y762 | EDGISyTTLRF | PhosphoSitePlus | |
| Y842 | QENVDyVILKH | PhosphoSitePlus | |
| Y796 | DDTVTySALHK | PhosphoSitePlus | |
| Y591 | TLEVLyAPRRL | PhosphoSitePlus | |
| Y822 | DEGIHySELIQ | PhosphoSitePlus | |
| Y807 | RQVGDyENVIP | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y822 | PEDEGIHySELIQFG | PTPN6 | HPRD |
| Y762 | MMEDGISyTTLRFPE | PTPN6 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339349 | R625C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000339349 | E592D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000085219 | G375E | COSMIC | Skin Cancer | 21984974 | ENSP00000085219 | C167F | COSMIC | Breast Cancer | 20668451 | ENSP00000085219 | R433* | COSMIC | Skin Cancer | 21984974 | ENSP00000085219 | R297H | COSMIC | Lung Cancer | 20668451 | ENSP00000085219 | R802C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000085219 | D791E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000085219 | S320L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000085219 | E769D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000085219 | W41* | COSMIC | Lung Cancer | 20668451 | ENSP00000085219 | H107R | COSMIC | Ovarian Cancer | 20668451 | ENSP00000085219 | N771K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CD22_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD22_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LYN_HUMAN | CD22_HUMAN | kinase -> substrate | NetPath |
| PTN6_HUMAN | CD22_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04662 | B cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |