| UniProt/SwissProt ID: | ELF1_HUMAN |
| Description: | E74-like factor 1 (ets domain transcription factor) [Source:HGNC Symbol;Acc:3316] |
| Location: | chr13 q14.11 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S168 | SPGASsPEQPK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S187 | PPRPDsPATTP | PhosphoSitePlus | |
| Y160 | QVQEKyADSPG | PhosphoSitePlus; HPRD | |
| S167 | DSPGAsSPEQP | PhosphoSitePlus; HPRD | |
| S195 | TTPNIsVKKKN | PhosphoSitePlus | |
| S110 | LLNMDsPGPML | HPRD | |
| S163 | EKYADsPGASS | PhosphoSitePlus; HPRD; phosphoELM | |
| S110 | LLNMDsPGPML | Elf-1_N | PhosphoSitePlus |
| T191 | DSPATtPNISV | PhosphoSitePlus | |
| T559 | TSVIKtQETKT | PhosphoSitePlus | |
| T231 | KYIKWtQREKG | Ets | PhosphoSitePlus |
| S376 | VQPTQsPYPTQ | PhosphoSitePlus | |
| S333 | RSRVSsSPGVK | PhosphoSitePlus | |
| S334 | SRVSSsPGVKG | PhosphoSitePlus | |
| S432 | VPVVVsPRNQQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S332 | SRSRVsSSPGV | PhosphoSitePlus | |
| S474 | QAIPSsQPMTV | PhosphoSitePlus; HPRD; phosphoELM | |
| Y261 | KPDMNyETMGR | Ets | PhosphoSitePlus |
| T190 | PDSPAtTPNIS | PhosphoSitePlus | |
| T566 | ETKTLtQEVEK | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| ELF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000239882 | P28S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000239882 | P225A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000239882 | L51V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000239882 | S604C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000239882 | *620Y | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| ELF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ELF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ELF1_HUMAN | NFKB1_HUMAN | TF -> target gene | TRANSFAC |
| ELF1_HUMAN | IL2RA_HUMAN | TF -> target gene | TRANSFAC |
| ELF1_HUMAN | IL2_HUMAN | TF -> target gene | TRANSFAC |
| ELF1_HUMAN | CD3Z_HUMAN | TF -> target gene | TRANSFAC |
| ELF1_HUMAN | LYN_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ELF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0001817 | regulation of cytokine production | IEA | biological_process |
| GO:0050860 | negative regulation of T cell receptor signaling p | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |