Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FCERB_HUMAN
Description:membrane-spanning 4-domains, subfamily A, member 2 [Source:HGNC Symbol;Acc:7316]
Location:chr11 q12.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y219PEDRVyEELNIPhosphoSitePlus; phosphoELM

Dephosphorylation site
FCERB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000278888M238TCOSMICOvarian Cancer21720365
ENSP00000278888C74FCOSMICHead and Neck Cancer21798893
ENSP00000278888E119QCOSMICHead and Neck Cancer21798893
ENSP00000278888M238TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
FCERB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FCERB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANFCERB_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04664Fc epsilon RI signaling pathway
hsa05310Asthma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0032998Fc-epsilon receptor I complexIEAcellular_component
GO:0051279regulation of release of sequestered calcium ion iIEAbiological_process
GO:0043306positive regulation of mast cell degranulationIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0005768endosomeIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0070588calcium ion transmembrane transportTASbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0009897external side of plasma membraneIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0050663cytokine secretionIEAbiological_process
GO:0005262calcium channel activityTASmolecular_function
GO:0019863IgE bindingIEAmolecular_function
GO:0007202activation of phospholipase C activityIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0051219phosphoprotein bindingIEAmolecular_function


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