Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PO2F1_HUMAN
Description:POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:9212]
Location:chr1 q24.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S167TQIPLsQPIQIPhosphoSitePlus
S448GGTSSsPIKAIPhosphoSitePlus; phosphoELM; RegPhos
S143QQHSAsQQHSAPhosphoSitePlus
S267QTLPQsQSTPKPhosphoSitePlus
T445PSSGGtSSSPIPhosphoSitePlus
S283SLEEPsDLEELphosphoELM
S141AVQQHsASQQHPhosphoSitePlus
T276PKRIDtPSLEEPhosphoSitePlus; phosphoELM
S81EESGDsQQPSQPhosphoSitePlus
S385RKKRTsIETNIPKA_groupphosphoELM; RegPhos
S92PSQQPsVQAAIPhosphoSitePlus
S447SGGTSsSPIKAPhosphoSitePlus; phosphoELM
S78KSNEEsGDSQQPhosphoSitePlus
T259RTIAAtPIQTLPhosphoSitePlus
S85DSQQPsQPSQQPhosphoSitePlus
S446SSGGTsSSPIKPhosphoSitePlus
T270PQSQStPKRIDPhosphoSitePlus; phosphoELM
S278RIDTPsLEEPSPhosphoSitePlus; phosphoELM
T100AAIPQtQLMLAPhosphoSitePlus
S283SLEEPsDLEELPouPhosphoSitePlus
S385RKKRTsIETNICDK7phosphoELM; RegPhos
S269LPQSQsTPKRIPhosphoSitePlus; phosphoELM
S232QLPQQsQANLLPhosphoSitePlus
S385RKKRTsIETNIphosphoELM
S385RKKRTsIETNIHomeoboxPhosphoSitePlus
T162AATPMtQIPLSPhosphoSitePlus
S88QPSQPsQQPSVPhosphoSitePlus
S335EALNLsFKNMCPouPhosphoSitePlus
T226AQNLLtQLPQQPhosphoSitePlus
S147ASQQHsAAGATPhosphoSitePlus

Dephosphorylation site
PO2F1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000453094R285QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356836R285QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000271411S88FSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
PO2F1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PO2F1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPO2F1_HUMANkinase -> substrateRegPhos
CDK7_HUMANPO2F1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PO2F1_HUMANH2B1J_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANINVO_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIGLL5_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANLIPL_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANLYN_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIL3_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANHBG1_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANCCND1_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIL2_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIL5_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANHBB_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANU2AFM_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANIGHA1_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANARY1_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANMYC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PO2F1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0006383transcription from RNA polymerase III promoterTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0060235lens induction in camera-type eyeIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0030910olfactory placode formationIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23