| UniProt/SwissProt ID: | CLNK_HUMAN |
| Description: | cytokine-dependent hematopoietic cell linker [Source:HGNC Symbol;Acc:17438] |
| Location: | chr4 p16.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T116 | PLDTRtSISIG | PhosphoSitePlus | |
| S338 | LVRDCsTKSKE | SH2 | PhosphoSitePlus |
| T339 | VRDCStKSKEE | SH2 | PhosphoSitePlus |
| S65 | GAKGHsDDDYD | PhosphoSitePlus | |
| Y357 | YENKVyNVKIR | SH2 | PhosphoSitePlus |
| Y40 | SATGQyQRMNK | PhosphoSitePlus | |
| S341 | DCSTKsKEEPY | SH2 | PhosphoSitePlus |
| Y352 | VLAVFyENKVY | SH2 | PhosphoSitePlus |
| S117 | LDTRTsISIGQ | PhosphoSitePlus | |
| Dephosphorylation site |
| CLNK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000226951 | K45R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CLNK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLNK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LYN_HUMAN | CLNK_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CLNK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | NAS | molecular_function |
| GO:0005622 | intracellular | NAS | cellular_component |