UniProt/SwissProt ID: | CASP7_HUMAN |
Description: | caspase 7, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1508] |
Location: | chr10 q25.3 |
Node attribute: | cleavage(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S30 | KPDRSsFVPSL | PhosphoSitePlus | |
S239 | SPGRGsWFVQA | Peptidase_C14 | PhosphoSitePlus |
S47 | NVTMRsIKTTR | PhosphoSitePlus | |
S16 | QGVEDsANEDS | HPRD | |
S37 | VPSLFsKKKKN | PhosphoSitePlus | |
S29 | AKPDRsSFVPS | PhosphoSitePlus | |
T173 | GDRCKtLLEKP | Peptidase_C14 | PhosphoSitePlus |
T44 | KKKNVtMRSIK | PhosphoSitePlus | |
S49 | QGVEDsANEDS | HPRD | |
Dephosphorylation site |
CASP7_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000358327 | V324L | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000358321 | V291L | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000358324 | V291L | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000298701 | V291L | TCGA | Ovarian Cancer | 21720365, 18772890 |
Differential expressed protein |
CASP7_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
CASP7_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
CASP7_HUMAN | LYN_HUMAN | cleavage | NetPath |
CASP7_HUMAN | TNR1A_HUMAN | cleavage | NetPath |
CASP7_HUMAN | ANDR_HUMAN | other | NetPath |
CASP7_HUMAN | IKKB_HUMAN | other | NetPath |
CASP7_HUMAN | KPCE_HUMAN | other | NetPath |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa05134 | Legionellosis |
hsa04210 | Apoptosis |
hsa05133 | Pertussis |
hsa05010 | Alzheimer's disease |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0006508 | proteolysis | IDA | biological_process |
GO:0006508 | proteolysis | IEA | biological_process |
GO:0001836 | release of cytochrome c from mitochondria | IEA | biological_process |
GO:0009411 | response to UV | IEA | biological_process |
GO:0006915 | apoptotic process | TAS | biological_process |
GO:0004197 | cysteine-type endopeptidase activity | IEA | molecular_function |
GO:0008233 | peptidase activity | IEA | molecular_function |
GO:0008635 | activation of cysteine-type endopeptidase activity | TAS | biological_process |
GO:0016485 | protein processing | IEA | biological_process |
GO:0008234 | cysteine-type peptidase activity | TAS | molecular_function |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0043525 | positive regulation of neuron apoptotic process | IEA | biological_process |
GO:0005654 | nucleoplasm | TAS | cellular_component |
GO:0006917 | induction of apoptosis | IEA | biological_process |
GO:0005737 | cytoplasm | IEA | cellular_component |
GO:0005634 | nucleus | IDA | cellular_component |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0004197 | cysteine-type endopeptidase activity | TAS | molecular_function |
GO:0004190 | aspartic-type endopeptidase activity | IEA | molecular_function |
GO:0005737 | cytoplasm | TAS | cellular_component |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0007507 | heart development | IEA | biological_process |
GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |