Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP7_HUMAN
Description:caspase 7, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1508]
Location:chr10 q25.3
Node attribute:cleavage(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S30KPDRSsFVPSLPhosphoSitePlus
S239SPGRGsWFVQAPeptidase_C14PhosphoSitePlus
S47NVTMRsIKTTRPhosphoSitePlus
S16QGVEDsANEDSHPRD
S37VPSLFsKKKKNPhosphoSitePlus
S29AKPDRsSFVPSPhosphoSitePlus
T173GDRCKtLLEKPPeptidase_C14PhosphoSitePlus
T44KKKNVtMRSIKPhosphoSitePlus
S49QGVEDsANEDSHPRD

Dephosphorylation site
CASP7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358327V324LCOSMICOvarian Cancer21720365
ENSP00000358321V291LTCGAOvarian Cancer21720365, 18772890
ENSP00000358324V291LTCGAOvarian Cancer21720365, 18772890
ENSP00000298701V291LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CASP7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASP7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CASP7_HUMANLYN_HUMANcleavageNetPath
CASP7_HUMANTNR1A_HUMANcleavageNetPath
CASP7_HUMANANDR_HUMANotherNetPath
CASP7_HUMANIKKB_HUMANotherNetPath
CASP7_HUMANKPCE_HUMANotherNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis
hsa04210Apoptosis
hsa05133Pertussis
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006508proteolysisIDAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0009411response to UVIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0008233peptidase activityIEAmolecular_function
GO:0008635activation of cysteine-type endopeptidase activityTASbiological_process
GO:0016485protein processingIEAbiological_process
GO:0008234cysteine-type peptidase activityTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006917induction of apoptosisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0004197cysteine-type endopeptidase activityTASmolecular_function
GO:0004190aspartic-type endopeptidase activityIEAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process


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