Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MDM4_HUMAN
Description:Mdm4 p53 binding protein homolog (mouse) [Source:HGNC Symbol;Acc:6974]
Location:chr1 q32.1
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T263ADTEQtSEEVGCriptPhosphoSitePlus
S342LTHSLsTSDITCHEK1HPRD
S342LTHSLsTSDITCHEK2HPRD
S391FDPCNsVEFLDHPRD
S403AHSSEsQETISATMHPRD
S367CRRTIsAPVVRPhosphoSitePlus; HPRD
S367CRRTIsAPVVRCHEK1HPRD
S367CRRTIsAPVVRCHEK2HPRD
Y55KEVMHyLGQYISWIBPhosphoSitePlus
S96SVKDPsPLYDMSWIBPhosphoSitePlus
T365PDCRRtISAPVPhosphoSitePlus; HPRD
S161PTLPTsEHKCIHPRD
Y99DPSPLyDMLRKSWIBPhosphoSitePlus
T119TDAAQtLALAQPhosphoSitePlus
S264DTEQTsEEVGKCriptPhosphoSitePlus
S342LTHSLsTSDITCriptPhosphoSitePlus
S289LEDSKsLSDDTCriptPhosphoSitePlus
S403AHSSEsQETISPhosphoSitePlus
S342LTHSLsTSDITAKT1HPRD

Dephosphorylation site
MDM4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356150S367LCOSMICHead and Neck Cancer
ENSP00000396840T160STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356150T160SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000356150S408LCOSMICHead and Neck Cancer21798893
ENSP00000356150R147KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356151Uterine CancerNormal vs. Cancercell lineUp11015838902

Hyperphosphorylation site
MDM4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMDM4_HUMANkinase -> substrateHPRD
KC1E_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANMDM4_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CLK2_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CHK1_HUMANMDM4_HUMANkinase -> substrateHPRD
UHMK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
HIPK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANMDM4_HUMANkinase -> substrateHPRD
KPCI_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
ACV1B_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MDM4_HUMANMDM2_HUMANotherKEGG
MDM4_HUMANP53_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008283cell proliferationIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0008270zinc ion bindingTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0006915apoptotic processIEPbiological_process
GO:0071157negative regulation of cell cycle arrestIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0006461protein complex assemblyIDAbiological_process
GO:0042177negative regulation of protein catabolic processIMPbiological_process
GO:0005634nucleusNAScellular_component
GO:0050821protein stabilizationIEPbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0045023G0 to G1 transitionIEPbiological_process