| UniProt/SwissProt ID: | PK3C3_HUMAN |
| Description: | phosphatidylinositol 3-kinase, catalytic subunit type 3 [Source:HGNC Symbol;Acc:8974] |
| Location: | chr18 q12.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T625 | QLFFKtEDGGK | HPRD | |
| T305 | VSYPPtKQLTY | PI3Ka | PhosphoSitePlus |
| S455 | LPSVSsPPPAS | PI3Ka | PhosphoSitePlus |
| T163 | KTPGRtSSTLS | PI3K_C2; tRNA_bind_2 | PhosphoSitePlus |
| S455 | LPSVSsPPPAS | HPRD | |
| Y395 | EDLLMyLLQLV | PI3Ka | PhosphoSitePlus |
| S454 | PLPSVsSPPPA | PI3Ka | PhosphoSitePlus |
| Y803 | FRKQCyTAFLH | PI3_PI4_kinase | PhosphoSitePlus |
| T488 | ACKNStLANYL | PI3Ka | PhosphoSitePlus |
| Y884 | HKFAQyWRK__ | PhosphoSitePlus | |
| Y379 | PTVRRyAVARL | PI3Ka | PhosphoSitePlus |
| T159 | SEPTKtPGRTS | PI3K_C2; tRNA_bind_2 | PhosphoSitePlus |
| S25 | QLKIGsLEGKR | PhosphoSitePlus | |
| S448 | SQIITsPLPSV | PI3Ka | PhosphoSitePlus |
| S448 | SQIITsPLPSV | HPRD | |
| S282 | LRSGPsDHDLK | PhosphoSitePlus | |
| S244 | DGDESsPILTS | PhosphoSitePlus; HPRD | |
| Y517 | KTHEMyLNVMR | PI3Ka | PhosphoSitePlus |
| S268 | ENLVEsKHHKL | PhosphoSitePlus | |
| S261 | PDPQMsMENLV | PhosphoSitePlus | |
| S164 | TPGRTsSTLSE | PI3K_C2; tRNA_bind_2 | PhosphoSitePlus |
| S165 | PGRTSsTLSED | PI3K_C2; tRNA_bind_2 | PhosphoSitePlus |
| T324 | FRYYLtNQEKA | PI3Ka | PhosphoSitePlus |
| T668 | LDLKLtPYKVL | PI3_PI4_kinase; DUF4135 | PhosphoSitePlus |
| Y322 | WKFRYyLTNQE | PI3Ka | PhosphoSitePlus |
| Y321 | VWKFRyYLTNQ | PI3Ka | PhosphoSitePlus |
| T513 | QRDPKtHEMYL | PI3Ka | PhosphoSitePlus |
| Dephosphorylation site |
| PK3C3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262039 | D314Y | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | D825Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000262039 | S699T | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | L330F | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | G788W | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | D99A | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000262039 | M187K | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | L593F | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000262039 | E711D | COSMIC | Lung Cancer |
| Differential expressed protein |
| PK3C3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PK3C3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PK3C3_HUMAN | CPSF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | SRS10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC2_HUMAN | PK3C3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | SRSF4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | MYF6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PK3C3_HUMAN | PINX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PK3C3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic proc | IMP | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005770 | late endosome | IDA | cellular_component |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IMP | molecular_function |
| GO:0000045 | autophagic vacuole assembly | IEA | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | IEA | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016485 | protein processing | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0045022 | early endosome to late endosome transport | IMP | biological_process |
| GO:0000910 | cytokinesis | IMP | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0043201 | response to leucine | IEA | biological_process |
| GO:0035004 | phosphatidylinositol 3-kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007032 | endosome organization | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0050708 | regulation of protein secretion | IEA | biological_process |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IEA | molecular_function |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030496 | midbody | IDA | cellular_component |