Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK3_HUMAN
Description:cyclin-dependent kinase 3 [Source:HGNC Symbol;Acc:1772]
Location:chr17 q25.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S207LFPGDsEIDQLphosphoELM
T198FAEMVtRKALFPkinasePhosphoSitePlus
T14KIGEGtYGVVYCDK3HPRD
T14KIGEGtYGVVYphosphoELM
Y19TYGVVyKAKNRphosphoELM
Y236TQLPDyKGSFPPkinasePhosphoSitePlus
T160PLRTYtHEVVTPkinasePhosphoSitePlus
Y19TYGVVyKAKNRCDK3HPRD
Y15IGEGTyGVVYKPkinasePhosphoSitePlus; SysPTM
T158GVPLRtYTHEVPkinasePhosphoSitePlus
T160PLRTYtHEVVTCDK3HPRD
Y19TYGVVyKAKNRPkinasePhosphoSitePlus
Y159VPLRTyTHEVVPkinasePhosphoSitePlus
T160PLRTYtHEVVTphosphoELM
S207LFPGDsEIDQLPkinasePhosphoSitePlus
T158GVPLRtYTHEVHPRD; phosphoELM
T14KIGEGtYGVVYPkinasePhosphoSitePlus
Y159VPLRTyTHEVVHPRD; phosphoELM
Y15IGEGTyGVVYKphosphoELM; SysPTM
S207LFPGDsEIDQLCDK3HPRD
Y15IGEGTyGVVYKCDK3HPRD; SysPTM

Dephosphorylation site
CDK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000400088S106NHPINeoplasms by Histologic Type17344846
ENSP00000410561S106NHPINeoplasms by Histologic Type17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000400088Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3618646787
ENSP00000400088Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3418646787
ENSP00000400088Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y15PkinaseEKIGEGTyGVVYKAKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDK3_HUMANCABL1_HUMANkinase -> substrateHPRD; RegPhos
CDK3_HUMANCDK3_HUMANkinase -> substrateHPRD
CDK3_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANKI3L1_HUMANkinase -> substrateHPRD
CDK3_HUMANPP2AA_HUMANkinase -> substrateRobert H Newman (2013)
CDK3_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CDK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0007067mitosisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0045023G0 to G1 transitionTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23