Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STK4_HUMAN
Description:serine/threonine kinase 4 [Source:HGNC Symbol;Acc:11408]
Location:chr20 q13.12
Node attribute:kinase; ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S82MQQCDsPHVVKPkinasePhosphoSitePlus
T387KRRDEtMQPAKPhosphoSitePlus
T440FLKSWtVEDLQMst1_SARAHPhosphoSitePlus
T177GQLTDtMAKRNPkinasePhosphoSitePlus
T187NTVIGtPFWMAMST1RegPhos
Y398PSFLEyFEQKEPhosphoSitePlus
T238IFMIPtNPPPTPkinasePhosphoSitePlus
T120RLRNKtLTEDEPkinasePhosphoSitePlus
Y433PQDGDyEFLKSHPRD; phosphoELM; RegPhos; SysPTM
T329EMDSGtMVRAVPhosphoSitePlus; HPRD
S414NSFGKsVPGPLPhosphoSitePlus
T243TNPPPtFRKPEHPRD
S327EDEMDsGTMVRSTK4HPRD
T177GQLTDtMAKRNSTK4HPRD
T367PSQLGtMVINAPhosphoSitePlus
S43EGSYGsVYKAIPkinasePhosphoSitePlus
T175VAGQLtDTMAKHPRD
Y45SYGSVyKAIHKPkinasePhosphoSitePlus
S423PLKNSsDWKIPPhosphoSitePlus
S438YEFLKsWTVEDMst1_SARAHPhosphoSitePlus; SysPTM
S327EDEMDsGTMVRPhosphoSitePlus
S307LKRQEsQQREVPhosphoSitePlus
Y41LGEGSyGSVYKPkinasePhosphoSitePlus
S265QCLVKsPEQRAPkinasePhosphoSitePlus; SysPTM
S410ENQINsFGKSVPhosphoSitePlus; HPRD; SysPTM
S320DDEENsEEDEMPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T243TNPPPtFRKPEPkinasePhosphoSitePlus
T340GDEMGtVRVASPhosphoSitePlus; HPRD; SysPTM
S40KLGEGsYGSVYPkinasePhosphoSitePlus
T183MAKRNtVIGTPSTK4HPRD
S438YEFLKsWTVEDHPRD; SysPTM
T238IFMIPtNPPPTHPRD
S422GPLKNsSDWKIPhosphoSitePlus
S132ATILQsTLKGLPkinasePhosphoSitePlus
S327EDEMDsGTMVRMST1RegPhos
T183MAKRNtVIGTPMST1phosphoELM; RegPhos
T380EEEEGtMKRRDPhosphoSitePlus
T177GQLTDtMAKRNMST1RegPhos
Y433PQDGDyEFLKSMst1_SARAHPhosphoSitePlus; SysPTM
T183MAKRNtVIGTPPkinasePhosphoSitePlus
T360IEHDDtLPSQLPhosphoSitePlus
S265QCLVKsPEQRAHPRD; SysPTM
T183MAKRNtVIGTPautocatalysisRegPhos
T3___MEtVQLRNPhosphoSitePlus
T187NTVIGtPFWMASTK4HPRD

Dephosphorylation site
STK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361892M143IBIOMARTBreast Cancer21930507, 21930502
ENSP00000361892R463QTCGAOvarian Cancer21720365, 18772890
ENSP00000379957M143IBIOMARTBreast Cancer21930507, 21930502
ENSP00000361887M143IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
STK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T120PkinaseIIRLRNKtLTEDEIAovarian cancer19940129PhosphoSitePlus
T183PkinaseDTMAKRNtVIGTPFWovarian cancer19940129PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANRON_HUMANligand -> receptorHPMR
STK4_HUMANH2B1H_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B1B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK4_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSTK4_HUMANkinase -> substrateRegPhos
STK4_HUMANFOXO3_HUMANkinase -> substrateRegPhos
STK4_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B1D_HUMANkinase -> substrateRegPhos
STK4_HUMANSTK4_HUMANkinase -> substrateRegPhos
STK4_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANRAD51_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B2F_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B1N_HUMANkinase -> substrateRegPhos
STK4_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B2E_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B2D_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B2C_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B3B_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B1J_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B1C_HUMANkinase -> substrateRegPhos
STK4_HUMANH2B1K_HUMANkinase -> substrateRegPhos
STK4_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B1O_HUMANkinase -> substrateRegPhos
STK4_HUMANH2BFS_HUMANkinase -> substrateRegPhos
STK4_HUMANSTK16_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B1L_HUMANkinase -> substrateRegPhos
STK4_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANH2B1M_HUMANkinase -> substrateRegPhos
STK4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
STK4_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05223Non-small cell lung cancer
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0001841neural tube formationIEAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0060215primitive hemopoiesisIEAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0043539protein serine/threonine kinase activator activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0060706cell differentiation involved in embryonic placentIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0035329hippo signaling cascadeTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007417central nervous system developmentIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0003157endocardium developmentIEAbiological_process
GO:0046983protein dimerization activityIDAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0035329hippo signaling cascadeIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0071902positive regulation of protein serine/threonine kiIDAbiological_process
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000902cell morphogenesisIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process


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