Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KC1E_HUMAN
Description:casein kinase 1, epsilon [Source:HGNC Symbol;Acc:2453]
Location:chr22 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S405SRIPAsQTSVPCSNK1EHPRD; SysPTM
T44LECVKtKHPQLPkinasePhosphoSitePlus
S400GRQEVsRIPASPhosphoSitePlus
S323GQLRGsATRALCSNK1EHPRD; SysPTM
S405SRIPAsQTSVPCK1_epsilonphosphoELM; SysPTM
T325LRGSAtRALPPCK1_groupphosphoELM; RegPhos
S390PANVSsSDLTGPhosphoSitePlus; HPRD
T407IPASQtSVPFDCK1_epsilonphosphoELM
S408PASQTsVPFDHCK1e(CK1 epsilonRegPhos; SysPTM
T407IPASQtSVPFDCK1eRegPhos
S323GQLRGsATRALCK1e(CK1 epsilonRegPhos; SysPTM
S343ANRLRsAAEPVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T407IPASQtSVPFDCK1e(CK1 epsilonRegPhos
T334PPGPPtGATANCSNK1EHPRD
S405SRIPAsQTSVPCK1_groupphosphoELM; RegPhos; SysPTM
S368SPRAIsRVDRECK1_groupphosphoELM; RegPhos
S389APANVsSSDLTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S354ASTPAsRIQPAPhosphoSitePlus; HPRD; SysPTM
T337PPTGAtANRLRCK1e(CK1 epsilonRegPhos
S377RERKVsMRLHRPhosphoSitePlus
S408PASQTsVPFDHPhosphoSitePlus; SysPTM
S368SPRAIsRVDREPhosphoSitePlus
S323GQLRGsATRALCK1_epsilonphosphoELM; SysPTM
T325LRGSAtRALPPCK1_epsilonphosphoELM
T325LRGSAtRALPPCSNK1EHPRD
T334PPGPPtGATANCK1_groupphosphoELM; RegPhos
T334PPGPPtGATANCK1e(CK1 epsilonRegPhos
S350AEPVAsTPASRPhosphoSitePlus; HPRD
S408PASQTsVPFDHCK1_epsilonphosphoELM; SysPTM
S17GRKIGsGSFGDPkinasePhosphoSitePlus
T337PPTGAtANRLRCK1eRegPhos
S368SPRAIsRVDRECSNK1EHPRD
T407IPASQtSVPFDCSNK1EHPRD
T337PPTGAtANRLRCK1_groupphosphoELM; RegPhos
S323GQLRGsATRALCK1_groupphosphoELM; RegPhos; SysPTM
S408PASQTsVPFDHCK1_groupphosphoELM; RegPhos; SysPTM
T407IPASQtSVPFDPhosphoSitePlus
S363PAGNTsPRAISPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S408PASQTsVPFDHCSNK1EHPRD; SysPTM
T334PPGPPtGATANCK1_epsilonphosphoELM
S368SPRAIsRVDRECK1_epsilonphosphoELM
T337PPTGAtANRLRCSNK1EHPRD
T351EPVAStPASRIPhosphoSitePlus; HPRD
T334PPGPPtGATANPhosphoSitePlus
T362QPAGNtSPRAIPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T325LRGSAtRALPPCK1e(CK1 epsilonRegPhos
T325LRGSAtRALPPCK1eRegPhos
T337PPTGAtANRLRPhosphoSitePlus
S368SPRAIsRVDRECK1eRegPhos
T407IPASQtSVPFDCK1_groupphosphoELM; RegPhos
T394SSSDLtGRQEVPhosphoSitePlus
S405SRIPAsQTSVPPhosphoSitePlus; SysPTM
T337PPTGAtANRLRCK1_epsilonphosphoELM
S323GQLRGsATRALPhosphoSitePlus; SysPTM
S405SRIPAsQTSVPCK1eRegPhos; SysPTM
S405SRIPAsQTSVPCK1e(CK1 epsilonRegPhos; SysPTM
S368SPRAIsRVDRECK1e(CK1 epsilonRegPhos
S391ANVSSsDLTGRPhosphoSitePlus; HPRD
S408PASQTsVPFDHCK1eRegPhos; SysPTM
T334PPGPPtGATANCK1eRegPhos
T325LRGSAtRALPPPhosphoSitePlus
S323GQLRGsATRALCK1eRegPhos; SysPTM

Dephosphorylation site
KC1E_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352929R256LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000384074N172KCOSMICOvarian Cancer21720365
ENSP00000383067R256LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000384074R256LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000380044R256LGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000380044Hepatocellular CarcinomaNormal vs. CancertissueDown0.5919956837

Hyperphosphorylation site
KC1E_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1E_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKC1E_HUMANkinase -> substrateRegPhos
KC1E_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPER2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1E_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANDVL2_HUMANkinase -> substrateNetPath
KC1E_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANKC1E_HUMANkinase -> substrateHPRD
KC1E_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANSKAP1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANDVL3_HUMANkinase -> substrateNetPath
KC1E_HUMANTFAM_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANDYN2_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANGEMI7_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANRMP_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANF110A_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANAPC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1E_HUMANDVL1_HUMANkinase -> substrateNetPath
KC1E_HUMAN2A5G_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANBID_HUMANkinase -> substrateHPRD
KC1E_HUMANPER3_HUMANkinase -> substrateHPRD
KC1E_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04710Circadian rhythm - mammal
hsa04340Hedgehog signaling pathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034613cellular protein localizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032436positive regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0004672protein kinase activityISSmolecular_function
GO:0006468protein phosphorylationISSbiological_process


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