Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CHK2_HUMAN
Description:checkpoint kinase 2 [Source:HGNC Symbol;Acc:16627]
Location:chr22 q12.1
Node attribute:Enzyme(source); substrate; kinase; Enzyme(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S41QGISSsSTSTMDUF966PhosphoSitePlus
S516VLAQPsTSRKRPhosphoSitePlus
T225YIMSKtLGSGAPkinasePhosphoSitePlus
T430RTLCGtPTYLACHEK2HPRD
S39QSQGIsSSSTSDUF966PhosphoSitePlus
S559VLAQPsTSRKRCHEK2HPRD
S12VEAQQsHGSSADUF966PhosphoSitePlus
S44SSSSTsTMPNSDUF966PhosphoSitePlus
S62SGTLSsLETVSDUF966PhosphoSitePlus
S28GSVTQsQGSSSATMHPRD; phosphoELM; RegPhos
S28GSVTQsQGSSSATRHPRD; RegPhos
S379ILGETsLMRTLPkinasePhosphoSitePlus
S456VWAEVsEKALDPkinasePhosphoSitePlus
S35GSSSQsQGISSATMHPRD; phosphoELM; RegPhos
S35GSSSQsQGISSATRHPRD; RegPhos
S40SQGISsSSTSTDUF966PhosphoSitePlus
T68LETVStQELYSCHK2phosphoELM; RegPhos
T68LETVStQELYSPLK1HPRD; phosphoELM; RegPhos
T68LETVStQELYSPLK3HPRD; RegPhos
T383TSLMRtLCGTPCHK2phosphoELM; RegPhos
S35GSSSQsQGISSDUF966PhosphoSitePlus
S19GSSACsQPHGSDUF966PhosphoSitePlus
T65LSSLEtVSTQEDUF966PhosphoSitePlus
T387RTLCGtPTYLACHEK2HPRD
T68LETVStQELYSCHEK2HPRD
T432FSEHRtQVSLKPkinasePhosphoSitePlus
T383TSLMRtLCGTPPkinasePhosphoSitePlus
T517LAQPStSRKRPPhosphoSitePlus
S24SQPHGsVTQSQDUF966PhosphoSitePlus
T43ISSSStSTMPNDUF966PhosphoSitePlus
T68LETVStQELYSATMHPRD; phosphoELM; RegPhos
S372TDFGHsKILGEPkinasePhosphoSitePlus
S33SQGSSsQSQGIATMHPRD; phosphoELM; RegPhos
S120FGRDKsCEYCFFHAPhosphoSitePlus
S19GSSACsQPHGSATRHPRD; RegPhos
S19GSSACsQPHGSATMHPRD; phosphoELM; RegPhos
S456VWAEVsEKALDphosphoELM
T378KILGEtSLMRTPkinasePhosphoSitePlus
S55SQSSHsSSGTLDUF966PhosphoSitePlus
Y390CGTPTyLAPEVPkinasePhosphoSitePlus
S164YIEDHsGNGTFFHAPhosphoSitePlus
S33SQGSSsQSQGIDUF966PhosphoSitePlus
T387RTLCGtPTYLACHK2phosphoELM; RegPhos
T26PHGSVtQSQGSPLK1HPRD; phosphoELM; RegPhos
S73TQELYsIPEDQDUF966PhosphoSitePlus
T68LETVStQELYSTTKphosphoELM
S15QQSHGsSACSQDUF966PhosphoSitePlus
S28GSVTQsQGSSSDUF966PhosphoSitePlus
S210TVDDQsVYPKAPhosphoSitePlus
S33SQGSSsQSQGIATRHPRD; RegPhos
T45SSSTStMPNSSDUF966PhosphoSitePlus
S260KFAIGsAREADPkinasePhosphoSitePlus
S50TMPNSsQSSHSATRHPRD; RegPhos
S50TMPNSsQSSHSATMHPRD; phosphoELM; RegPhos
T26PHGSVtQSQGSATRHPRD; RegPhos
T26PHGSVtQSQGSATMHPRD; phosphoELM; RegPhos
S42GISSSsTSTMPDUF966PhosphoSitePlus
S435HRTQVsLKDQIPkinasePhosphoSitePlus
T389LCGTPtYLAPEPkinasePhosphoSitePlus
S50TMPNSsQSSHSDUF966PhosphoSitePlus
S67SLETVsTQELYDUF966PhosphoSitePlus
S52PNSSQsSHSSSDUF966PhosphoSitePlus
T426TSLMRtLCGTPCHEK2HPRD
T68LETVStQELYSDUF966PhosphoSitePlus
T68LETVStQELYSZAKRegPhos
T383TSLMRtLCGTPCHEK2HPRD
S487VLAQPsTSRKRCHEK2HPRD
T354TSLMRtLCGTPCHEK2HPRD
S140KYRTYsKKHFRFHAPhosphoSitePlus
S516VLAQPsTSRKRCHEK2HPRD
T358RTLCGtPTYLACHEK2HPRD
S516VLAQPsTSRKRCHK2phosphoELM; RegPhos
T205VFFDLtVDDQSPhosphoSitePlus
T387RTLCGtPTYLAPkinasePhosphoSitePlus
T26PHGSVtQSQGSDUF966PhosphoSitePlus

Dephosphorylation site
CHK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000329178R145PHPIProstate Cancer12533788
ENSP00000385747T323PHPIProstate Cancer12533788
ENSP00000385747E64KHPIProstate Cancer12533788
ENSP00000329178T59KHPIOther Cancer12052256
ENSP00000329178A17SOMIM, HPISarcoma11746983
ENSP00000385747T476KHPIProstate Cancer12533788
ENSP00000329178S428FOMIMBreast Cancer15649950
ENSP00000329178I157TOMIMColorectal Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000329178I157TOMIMProstate Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000329178E239KOMIM, HPIProstate Cancer12533788
ENSP00000385747I157TOMIMOther Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000386087T59KHPIOther Cancer12052256
ENSP00000329178R318HHPIProstate Cancer12533788
ENSP00000386087E239KOMIM, HPIProstate Cancer12533788
ENSP00000386087I157TOMIMColorectal Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000385747G167RHPIProstate Cancer12533788
ENSP00000329178I157TOMIMOther Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000329178R180HOMIM, HPIProstate Cancer12533788, 12454775 12533788 15818573
ENSP00000329178G167RHPIProstate Cancer12533788
ENSP00000386087G167RHPIProstate Cancer12533788
ENSP00000385747R145PHPIProstate Cancer12533788
ENSP00000386087R145PHPIProstate Cancer12533788
ENSP00000385747S428FOMIMBreast Cancer15649950
ENSP00000386087I157TOMIMOther Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000385747I251FHPIProstate Cancer12533788
ENSP00000329178T323PHPIProstate Cancer12533788
ENSP00000329178R181HOMIM, HPIProstate Cancer12533788
ENSP00000385747I157TOMIMProstate Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000385747R318HHPIProstate Cancer12533788
ENSP00000385747Y327CHPIProstate Cancer12533788
ENSP00000386087R181HOMIM, HPIProstate Cancer12533788
ENSP00000385747R180HOMIM, HPIProstate Cancer12533788, 12454775 12533788 15818573
ENSP00000385747A17SOMIM, HPISarcoma11746983
ENSP00000329178Y327CHPIProstate Cancer12533788
ENSP00000386087T476KHPIProstate Cancer12533788
ENSP00000386087I251FHPIProstate Cancer12533788
ENSP00000385747R181HOMIM, HPIProstate Cancer12533788
ENSP00000385747I157TOMIMColorectal Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000329178I251FHPIProstate Cancer12533788
ENSP00000386087A17SOMIM, HPISarcoma11746983
ENSP00000386087T323PHPIProstate Cancer12533788
ENSP00000329178P85LOMIM, HPISarcoma11746983, 11746983 15649950 17721994
ENSP00000386087Y327CHPIProstate Cancer12533788
ENSP00000385747E239KOMIM, HPIProstate Cancer12533788
ENSP00000386087I157TOMIMProstate Cancer10617473 12533788 15239132 15492928 16816021 17085682
ENSP00000385747P85LOMIM, HPISarcoma11746983, 11746983 15649950 17721994
ENSP00000329178T476KHPIProstate Cancer12533788
ENSP00000385747T59KHPIOther Cancer12052256
ENSP00000386087R318HHPIProstate Cancer12533788
ENSP00000386087E64KHPIProstate Cancer12533788
ENSP00000329178E64KHPIProstate Cancer12533788
ENSP00000386087R180HOMIM, HPIProstate Cancer12533788, 12454775 12533788 15818573
ENSP00000386087P85LOMIM, HPISarcoma11746983, 11746983 15649950 17721994
ENSP00000386087S428FOMIMBreast Cancer15649950

Differential expressed protein
CHK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T68DUF966SSLETVStQELYSIPsmall-cell lung cancer16705183PhosphoSitePlus
T68DUF966SSLETVStQELYSIPbladder cancer15361851PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CHK2_HUMANMDM4_HUMANkinase -> substrateHPRD
MARK3_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMPIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ATR_HUMANCHK2_HUMANkinase -> substrateRegPhos
CHK2_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
CDKL5_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
MLTK_HUMANCHK2_HUMANkinase -> substrateRegPhos
PLK3_HUMANCHK2_HUMANkinase -> substrateHPRD; RegPhos
CHK2_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANCHK2_HUMANkinase -> substrateRegPhos
CHK2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANP53_HUMANkinase -> substrateKEGG; RegPhos; Robert H Newman (2013)
JAK2_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANE2F1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CHK2_HUMANBRCA1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CHK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CHK2_HUMANLRIG1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANCHK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK9_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANCHK2_HUMANkinase -> substrateRegPhos
E2AK2_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANAATF_HUMANkinase -> substrateHPRD
CHK2_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANDGKA_HUMANenzyme catalysisKEGG
CDIPT_HUMANCHK2_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0000077DNA damage checkpointIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000086G2/M transition of mitotic cell cycleIMPbiological_process
GO:0008630intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0090307spindle assembly involved in mitosisIMPbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0016605PML bodyIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0016301kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0090399replicative senescenceNASbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0044257cellular protein catabolic processIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0042770signal transduction in response to DNA damageIEAbiological_process
GO:0072428signal transduction involved in intra-S DNA damageIMPbiological_process
GO:0042770signal transduction in response to DNA damageIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0006302double-strand break repairIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0000077DNA damage checkpointTASbiological_process
GO:0042176regulation of protein catabolic processIMPbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006975DNA damage induced protein phosphorylationIMPbiological_process


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