Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RIOK1_HUMAN
Description:RIO kinase 1 [Source:HGNC Symbol;Acc:18656]
Location:chr6 p24.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S102TSDSSsAKMSTPhosphoSitePlus
S22DDADSsDSENRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y223KDRDKyVSGEFRIO1PhosphoSitePlus
T470LYQTVtGLKKDPhosphoSitePlus
T509SECSDtDSEEQPhosphoSitePlus
Y466QDNILyQTVTGPhosphoSitePlus
S21FDDADsSDSENPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S24ADSSDsENRDLPhosphoSitePlus; HPRD; phosphoELM
T175LFKMLtRGIITPhosphoSitePlus
Y440NEVKNyERDMDPhosphoSitePlus
T468NILYQtVTGLKPhosphoSitePlus
T107SAKMStPADKVPhosphoSitePlus
Y83KLAKGyVWNGGPhosphoSitePlus
T494QVEERtCSDSEPhosphoSitePlus

Dephosphorylation site
RIOK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369162V76ABIOMARTPancreatic Cancer21930507, 21930502
ENSP00000369162D526GTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RIOK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RIOK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RIOK1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RIOK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function