Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PHS_HUMAN
Description:pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:HGNC Symbol;Acc:8646]
Location:chr10 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S9KAHRLsAEERDHPRD

Dephosphorylation site
PHS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299299I34MBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000299299Hepatocellular CarcinomaNormal vs. Cancercell lineUp3.418646787
ENSP00000299299Breast CancerNormal vs. CancertissueUp0.6720739354
ENSP00000299299Breast CancerNormal vs. CancertissueUp0.6720739354

Hyperphosphorylation site
PHS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC1_HUMANPHS_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANPHS_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANPHS_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PHS_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0051289protein homotetramerizationIEAbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0051291protein heterooligomerizationIEAbiological_process
GO:00081244-alpha-hydroxytetrahydrobiopterin dehydratase actEXPmolecular_function
GO:0006559L-phenylalanine catabolic processTASbiological_process
GO:0006729tetrahydrobiopterin biosynthetic processIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0004505phenylalanine 4-monooxygenase activityIEAmolecular_function
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0043496regulation of protein homodimerization activityIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process


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