Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMR1B_HUMAN
Description:bone morphogenetic protein receptor, type IB [Source:HGNC Symbol;Acc:1077]
Location:chr4 q22.3
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S402MADMYsFGLILPkinasePhosphoSitePlus
Y290GSLYDyLKSTTPkinasePhosphoSitePlus
S300TLDAKsMLKLAPkinasePhosphoSitePlus

Dephosphorylation site
BMR1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000426617N44YCOSMICOvarian Cancer21720365
ENSP00000264568D297NGreenman2007Skin Cancer17344846, 18428421
ENSP00000378389D297NGreenman2007Skin Cancer17344846, 18428421
ENSP00000426617E94VCOSMICMelanoma21499247
ENSP00000378389G63WDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000378389R31HGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000264568G63WDing2008Lung Cancer18948947
ENSP00000264568R31HGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000264568P157RDing2008Lung Cancer18948947
ENSP00000378389P157RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
BMR1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMR1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMP15_HUMANBMR1B_HUMANligand -> receptorHPMR
BMP2_HUMANBMR1B_HUMANligand -> receptorHPMR
BMP4_HUMANBMR1B_HUMANligand -> receptorHPMR
BMP7_HUMANBMR1B_HUMANligand -> receptorHPMR
BMR1B_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSTABP_HUMANkinase -> substrateRegPhos
BMR1B_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANFR1OP_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSMAD1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BMR1B_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANIFI27_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANDNJB2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANPHB2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneICcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0001654eye developmentISSbiological_process
GO:0001502cartilage condensationIEAbiological_process
GO:0001501skeletal system developmentIMPbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0042698ovulation cycleIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0004675transmembrane receptor protein serine/threonine kiNASmolecular_function
GO:0043235receptor complexTAScellular_component
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0042698ovulation cycleISSbiological_process
GO:0001654eye developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043010camera-type eye developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0001550ovarian cumulus expansionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0005025transforming growth factor beta receptor activity,IEAmolecular_function
GO:0035108limb morphogenesisIMPbiological_process
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006954inflammatory responseIEAbiological_process
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0045597positive regulation of cell differentiationIMPbiological_process


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