Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CP250_HUMAN
Description:centrosomal protein 250kDa [Source:HGNC Symbol;Acc:1859]
Location:chr20 q11.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S581SIAELsSSENTHPRD
S2417RRLDEsLTQSLPhosphoSitePlus
S1601DLEERsQELQAPhosphoSitePlus
S1310EGKQNsLESELHPRD
T2218DELELtRRALEPhosphoSitePlus
S2421ESLTQsLTSPGPhosphoSitePlus
S2322AAQAGsLEISKPhosphoSitePlus
S2392LHHSLsHSLLAPhosphoSitePlus
S929EKERVsLLETLPhosphoSitePlus
S295ALLTQsQKQNEPhosphoSitePlus
S1313QNSLEsELMELPhosphoSitePlus; HPRD
T1701GRELTtQRQLMPhosphoSitePlus
Y2373KQKQDyITRSAPhosphoSitePlus
S583AELSSsENTLKHPRD
T2364LQAQLtLERKQPhosphoSitePlus
T933VSLLEtLLQTQPhosphoSitePlus
T2419LDESLtQSLTSPhosphoSitePlus
S1295LQRQLsQNQEEPhosphoSitePlus
T186WREVVtFRRHFPhosphoSitePlus
S1386LRTARsALKLKPhosphoSitePlus
S1618DLESHsTVLARPhosphoSitePlus
T1040EKLREtQEYNRPhosphoSitePlus
S1609LQAQSsQIHDLPhosphoSitePlus
S1324HETMAsLQSRLHPRD
T1853EQAHMtLKERHPhosphoSitePlus
S2229KERLHsPGATSPhosphoSitePlus
T971TGILQtQLQEAPhosphoSitePlus
S2234SPGATsTAELGPhosphoSitePlus
S2179QDLALsLAQTKPhosphoSitePlus
T54QQRQAtLVRKLPhosphoSitePlus
S1060ASLTLsLMEKEHPRD
T842EQEGKtALEQQPhosphoSitePlus
S2252QLGEVsGVEAEPhosphoSitePlus
S45RKLKNsQEAQQPhosphoSitePlus
S2259VEAEPsPDGMEPhosphoSitePlus
S2394HSLSHsLLAVAPhosphoSitePlus
T293LSALLtQSQKQPhosphoSitePlus

Dephosphorylation site
CP250_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380661S1187PCOSMICOvarian Cancer21720365
ENSP00000380661T796ICOSMICCentral Nervous System Neoplasms
ENSP00000380661E47KCOSMICOvarian Cancer21720365
ENSP00000380661E1887GTCGAOvarian Cancer21720365, 18772890
ENSP00000380661E1887GCOSMICOvarian Cancer21720365

Differential expressed protein
CP250_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CP250_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC1_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CP250_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008104protein localizationIMPbiological_process
GO:0000278mitotic cell cycleIDAbiological_process
GO:0005815microtubule organizing centerNAScellular_component
GO:0005813centrosomeIDAcellular_component
GO:0043234protein complexIMPcellular_component
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0031616spindle pole centrosomeIEAcellular_component
GO:0005932microtubule basal bodyIEAcellular_component
GO:0005814centrioleIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0030997regulation of centriole-centriole cohesionIDAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005929ciliumIEAcellular_component
GO:0010457centriole-centriole cohesionIMPbiological_process


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