Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DCLK1_HUMAN
Description:doublecortin-like kinase 1 [Source:HGNC Symbol;Acc:2700]
Location:chr13 q13.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S330PRSGKsPSPSPPhosphoSitePlus; HPRD
S337SPSPTsPGSLRPhosphoSitePlus; HPRD
S738VRSPNsPF___PhosphoSitePlus
S334KSPSPsPTSPGPhosphoSitePlus; HPRD
S353QHGGSsTSLASPhosphoSitePlus
S327LSTPRsGKSPSPhosphoSitePlus
S32VNGLPsPTHSAPhosphoSitePlus
S332SGKSPsPSPTSPhosphoSitePlus; HPRD
S729DYSPSsSETVRPhosphoSitePlus
S313PASTSsVNGTPPhosphoSitePlus
S305GPSRRsKSPASPhosphoSitePlus
S312SPASTsSVNGTPhosphoSitePlus
S274FLLDEsECRVVPhosphoSitePlus
T324GSQLStPRSGKPhosphoSitePlus
T336PSPSPtSPGSLPhosphoSitePlus; HPRD
T46FYRTRtLQTLSPhosphoSitePlus
T34GLPSPtHSAHCPhosphoSitePlus
S164ASRAVsSLATAPhosphoSitePlus
Y265PEKFRyQDDFLPhosphoSitePlus
S352SQHGGsSTSLAPhosphoSitePlus; HPRD
S340PTSPGsLRKQRPhosphoSitePlus
S307SRRSKsPASTSPhosphoSitePlus

Dephosphorylation site
DCLK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353846R93QGreenman2007, HPIGastric Cancer17344846
ENSP00000255448T46MGreenman2007Gastric Cancer17344846
ENSP00000255448*730YCOSMICLung Cancer18948947
ENSP00000369223*434YCOSMICOvarian Cancer20826764
ENSP00000255448R93QGreenman2007Gastric Cancer17344846
ENSP00000353846R82LBIOMARTBreast Cancer21930507, 21930502
ENSP00000353846S291FGreenman2007, HPIGastric Cancer17344846
ENSP00000255448S291FGreenman2007Gastric Cancer17344846
ENSP00000255448R82LBIOMARTBreast Cancer21930507, 21930502
ENSP00000255448G29CGreenman2007Gastric Cancer17344846
ENSP00000353846T46MGreenman2007, HPIGastric Cancer17344846
ENSP00000353846G29CGreenman2007, HPIGastric Cancer17344846

Differential expressed protein
DCLK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DCLK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DCLK1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
DCLK1_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
DCLK1_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DCLK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007420brain developmentIEAbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007399nervous system developmentTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0048675axon extensionIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0009615response to virusIEPbiological_process
GO:0048813dendrite morphogenesisIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0016197endosomal transportNASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0021952central nervous system projection neuron axonogeneIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0001764neuron migrationIEAbiological_process


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